Mice with a targeted mutation in the myogenic basic helix-loop-helix regulatory protein
myogenin have severe muscle defects resulting in perinatal death. In this report, the effect of …

In the preimplantation mouse embryo, TEAD4 is critical to establishing the trophectoderm (TE)-specific
transcriptional program and segregating TE from the inner cell mass (ICM). …

Histone methylation is an important regulator of gene expression; its coordinated activity is
critical in complex developmental processes such as hematopoiesis. Disruptor of telomere …

Epithelial barrier integrity is dependent on progenitor cells that either divide to replenish
themselves or differentiate into a specialized epithelium. This paradigm exists in human placenta…

Invasive trophoblast cells are critical to spiral artery remodeling in hemochorial placentation.
Insufficient trophoblast cell invasion and vascular remodeling can lead to pregnancy …

The progesterone receptor (PGR) is a ligand-activated transcription factor with key roles in
the regulation of female fertility. Much has been learned of the actions of PGR signaling …

Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens
are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse …

Because of their deleterious effects on developing organisms, ribosomal protein (RP) mutations
have been poorly described in mammals, and only a few heterozygous mutations have …

Estrogens play pivotal roles in development and function of many organ systems, including
the reproductive system. We have generated estrogen receptor 1 (Esr1)-knockout rats using …

Members of the transforming growth factor-β superfamily play essential roles in both the
pluripotency and differentiation of embryonic stem (ES) cells. Although bone morphogenic …