[HTML][HTML] Adjuvanting a subunit COVID-19 vaccine to induce protective immunity
…, G Alter, F Villinger, H Kleanthous, J Rappaport… - Nature, 2021 - nature.com
The development of a portfolio of COVID-19 vaccines to vaccinate the global population
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …
CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection
…, S Amini, S Morgello, K Khalili, J Rappaport - Journal of …, 2001 - Springer
Increases in circulating CD14+/CD16+ monocytes have been associated with HIV dementia;
trafficking of these cells into the CNS has been proposed to play an important role in the …
trafficking of these cells into the CNS has been proposed to play an important role in the …
[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS
…, F Schächter, D Zagury, J Rappaport… - The Journal of …, 1999 - journals.aai.org
The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid
progressors to AIDS corresponding to the extremes of HIV disease outcome of 20,000 …
progressors to AIDS corresponding to the extremes of HIV disease outcome of 20,000 …
[HTML][HTML] SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …
A smartphone-read ultrasensitive and quantitative saliva test for COVID-19
Point-of-care COVID-19 assays that are more sensitive than the current RT-PCR (reverse
transcription polymerase chain reaction) gold standard assay are needed to improve disease …
transcription polymerase chain reaction) gold standard assay are needed to improve disease …
[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19
…, S Ergün, F Mauvais-Jarvis, J Rappaport… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …
[HTML][HTML] HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention
M Kogan, J Rappaport - Retrovirology, 2011 - Springer
The HIV protein, Vpr, is a multifunctional accessory protein critical for efficient viral infection
of target CD4 + T cells and macrophages. Vpr is incorporated into virions and functions to …
of target CD4 + T cells and macrophages. Vpr is incorporated into virions and functions to …
[HTML][HTML] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
…, R Bohm, LA Doyle-Meyers, J Rappaport… - Nature …, 2022 - nature.com
Neurological manifestations are a significant complication of coronavirus disease (COVID-19),
but underlying mechanisms aren’t well understood. The development of animal models …
but underlying mechanisms aren’t well understood. The development of animal models …
Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine
…, F Villinger, H Kleanthous, J Rappaport… - Science translational …, 2022 - science.org
Despite the remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence
of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we …
of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we …