The development of a portfolio of COVID-19 vaccines to vaccinate the global population
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …

Increases in circulating CD14+/CD16+ monocytes have been associated with HIV dementia;
trafficking of these cells into the CNS has been proposed to play an important role in the …

The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …

The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid
progressors to AIDS corresponding to the extremes of HIV disease outcome of 20,000 …

SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …

Point-of-care COVID-19 assays that are more sensitive than the current RT-PCR (reverse
transcription polymerase chain reaction) gold standard assay are needed to improve disease …

Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …

The HIV protein, Vpr, is a multifunctional accessory protein critical for efficient viral infection
of target CD4 + T cells and macrophages. Vpr is incorporated into virions and functions to …

Neurological manifestations are a significant complication of coronavirus disease (COVID-19),
but underlying mechanisms aren’t well understood. The development of animal models …

Despite the remarkable efficacy of COVID-19 vaccines, waning immunity and the emergence
of SARS-CoV-2 variants such as Omicron represents a global health challenge. Here, we …