Modulating the chemical composition of cereblon (CRBN) binders is a critical step in the
optimization process of protein degraders that seek to hijack the function of this E3 ligase. Small …

Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S.
haematobium, and S. japonicum. Praziquantel (PZQ) is the method of choice for treatment. …

Human schistosomiasis is a debilitating, life-threatening disease affecting more than 229
million people in as many as 78 countries. There is only one drug of choice effective against all …

Human schistosomiasis, one of the most important neglected tropical diseases caused by
parasitic worms of the genus Schistosoma. It is accompanied by severe clinical symptoms as …

Effecting more than 290 million people in over 78 countries and only one current treatment in
use, the parasitic disease human schistosomiasis is in danger of producing drug resistance …

The general structure of a quaternary ammonium compound (QAC) consist of a positively
charged quaternary amine and a lipophilic tail1 and pictured in figure 1 with a comparison to …

… Taylor, a Jayce Rhodes, c Frédéric D. Chevalier, d Timothy Jc Anderson, e and Stanton F.
McHardy c …

Human schistosomiasis is a neglected tropical disease caused by parasitic worms. It affects
over 250 million people globally. Most human infections are caused by S. mansoni, S. …

The annual NIH report states that pain affects more Americans than diabetes, heart disease,
and cancer combined. Furthermore, chronic pain is the most common cause of long-term …

Triple-negative breast cancer (TNBC) accounts for 10-15% of all total breast cancer cases,
but has a much lower survival rate than its hormone-receptor counterparts. Currently, TNBC is …