A mechanism for the suppression of homologous recombination in G1 cells
…, RI Enchev, A Sherker, M Munro, J Pinder, J Salsman… - Nature, 2015 - nature.com
DNA repair by homologous recombination 1 is highly suppressed in G1 cells 2 , 3 to ensure
that mitotic recombination occurs solely between sister chromatids 4 . Although many …
that mitotic recombination occurs solely between sister chromatids 4 . Although many …
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines
JS Mader, J Salsman, DM Conrad, DW Hoskin - Molecular cancer …, 2005 - AACR
Bovine lactoferricin (LfcinB) is a cationic, amphipathic peptide that is cytotoxic for human and
rodent cancer cells. However, the mechanism by which LfcinB causes the death of cancer …
rodent cancer cells. However, the mechanism by which LfcinB causes the death of cancer …
Nuclear domain 'knock-in'screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
J Pinder, J Salsman, G Dellaire - Nucleic acids research, 2015 - academic.oup.com
CRISPR is a genome-editing platform that makes use of the bacterially-derived endonuclease
Cas9 to introduce DNA double-strand breaks at precise locations in the genome using …
Cas9 to introduce DNA double-strand breaks at precise locations in the genome using …
Precision genome editing in the CRISPR era
J Salsman, G Dellaire - Biochemistry and cell biology, 2017 - cdnsciencepub.com
With the introduction of precision genome editing using CRISPR–Cas9 technology, we
have entered a new era of genetic engineering and gene therapy. With RNA-guided …
have entered a new era of genetic engineering and gene therapy. With RNA-guided …
Marker-free coselection for CRISPR-driven genome editing in human cells
…, J Loehr, D Synodinou, M Drouin, J Salsman… - Nature …, 2017 - nature.com
Targeted genome editing enables the creation of bona fide cellular models for biological
research and may be applied to human cell-based therapies. Therefore, broadly applicable and …
research and may be applied to human cell-based therapies. Therefore, broadly applicable and …
[HTML][HTML] Genome-wide screen of three herpesviruses for protein subcellular localization and alteration of PML nuclear bodies
J Salsman, N Zimmerman, T Chen, M Domagala… - PLoS …, 2008 - journals.plos.org
Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many
of the proteins encoded by these viruses have not been functionally characterized. As a first …
of the proteins encoded by these viruses have not been functionally characterized. As a first …
Extensive syncytium formation mediated by the reovirus FAST proteins triggers apoptosis-induced membrane instability
The fusion-associated small transmembrane (FAST) proteins of the fusogenic reoviruses are
the only known examples of membrane fusion proteins encoded by nonenveloped viruses. …
the only known examples of membrane fusion proteins encoded by nonenveloped viruses. …
Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria
JS Mader, A Richardson, J Salsman, D Top… - Experimental cell …, 2007 - Elsevier
Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide that kills Jurkat T-leukemia cells
by the mitochondrial pathway of apoptosis. However, the process by which LfcinB triggers …
by the mitochondrial pathway of apoptosis. However, the process by which LfcinB triggers …
Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response
J Salsman, M Jagannathan, P Paladino… - Journal of …, 2012 - Am Soc Microbiol
Human cytomegalovirus infections involve the extensive modification of host cell pathways,
including cell cycle control, the regulation of the DNA damage response, and averting …
including cell cycle control, the regulation of the DNA damage response, and averting …
Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival
…, T Selman, E Nguyen, J Salsman… - Molecular and Cellular …, 2019 - Springer
Bitter taste receptors (Tas2Rs) are a subfamily of G-protein coupled receptors expressed
not only in the oral cavity but also in several extra-oral tissues and disease states. Several …
not only in the oral cavity but also in several extra-oral tissues and disease states. Several …