A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
JP Olivier, T Raabe, M Henkemeyer, B Dickson… - Cell, 1993 - cell.com
A Drosophlla gene (drk) encodes a widely expressed protein with a single SH2 domain and
two flanking SH3 domains, which is homologous to the Sem-5 protein of C. elegans and …
two flanking SH3 domains, which is homologous to the Sem-5 protein of C. elegans and …
Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient …
O Zhang, LE Kay, JP Olivier, JD Forman-Kay - Journal of biomolecular …, 1994 - Springer
The backbone 1 H and 15 N resonances of the N-terminal SH3 domain of the Drosophila
signaling adapter protein, drk, have been assigned. This domain is in slow exchange on the …
signaling adapter protein, drk, have been assigned. This domain is in slow exchange on the …
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape
The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic
antibodies and urgently demands powerful new therapeutics that can resist viral escape. We …
antibodies and urgently demands powerful new therapeutics that can resist viral escape. We …
Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis
M Henkemeyer, LE Marengere, J McGlade, JP Olivier… - 1994 - tspace.library.utoronto.ca
Neural kinase (Nuk) encodes a murine receptor-like tyrosine kinase belonging to the Eph/Elk/Eck
family. Protein localization studies indicate that during early embryogenesis Nuk is …
family. Protein localization studies indicate that during early embryogenesis Nuk is …
[PDF][PDF] A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides
Background: Signal transduction by growth factor receptor protein-tyrosine kinases is
generally initiated by autophosphorylation on tyrosine residues following ligand binding. …
generally initiated by autophosphorylation on tyrosine residues following ligand binding. …
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.
T Raabe, JP Olivier, B Dickson, X Liu, GD Gish… - The EMBO …, 1995 - embopress.org
The Drk SH3‐SH2‐SH3 adaptor protein has been genetically identified in a screen for rate‐limiting
components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in …
components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in …
[HTML][HTML] Cyclin I protects podocytes from apoptosis
SV Griffin, JP Olivier, JW Pippin, JM Roberts… - Journal of biological …, 2006 - ASBMB
The limited regenerative capacity of the glomerular podocyte following injury underlies the
development of glomerulosclerosis and progressive renal failure in a diverse range of kidney …
development of glomerulosclerosis and progressive renal failure in a diverse range of kidney …
A Drosophila shc Gene Product Is Implicated in Signaling by the DER Receptor Tyrosine Kinase
KMV Lai, JP Olivier, GD Gish… - … and cellular biology, 1995 - Taylor & Francis
Antibodies to the human Shc adaptor protein were used to isolate a cDNA encoding a
Drosophila Shc protein (dShc) by screening an expression library. The dshc gene, which maps to …
Drosophila Shc protein (dShc) by screening an expression library. The dshc gene, which maps to …
[HTML][HTML] Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus
To date, all major modes of monoclonal antibody therapy targeting SARS-CoV-2 have lost
significant efficacy against the latest circulating variants. As SARS-CoV-2 omicron …
significant efficacy against the latest circulating variants. As SARS-CoV-2 omicron …
[HTML][HTML] Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication
CC Carter, FD Mast, JP Olivier… - Frontiers in cellular …, 2022 - frontiersin.org
The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1,
and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including …
and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including …