The genetic architecture of the human cerebral cortex

…, PR Schofield, R Secolin, CY Shapland, L Shen, J Shin… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …

Common genetic variants influence human subcortical brain structures

…, A Salami, PG Sämann, L Schmaal, AJ Schork, J Shin… - Nature, 2015 - nature.com
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

Novel genetic loci underlying human intracranial volume identified through genome-wide association

…, L Schmaal, AJ Schork, L Shen, J Shin… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

…, M Kerick, C Wang, P Melton, HR Elliott, J Shin… - Nature …, 2021 - nature.com
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

Graduate students of color: Race, racism, and mentoring in the white waters of academia

…, DG Embrick, JH Shin - Sociology of race and …, 2017 - journals.sagepub.com
The graduate student experience, for many, can be a time of great stress, insecurity, and
uncertainty. Overwhelmingly, studies verify that good mentoring is one of the best indicators of …

[HTML][HTML] Novel genetic loci associated with hippocampal volume

…, L Schmaal, AJ Schork, L Shen, J Shin… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an …

…, R Richmond, P Hu, L French, J Shin… - Environmental …, 2015 - ehp.niehs.nih.gov
Background: Prenatal exposure to maternal cigarette smoking (prenatal smoke exposure)
had been associated with altered DNA methylation (DNAm) at birth. Objective: We examined …

Genetic architecture of subcortical brain structures in 38,851 individuals

…, E Walton, D Tordesillas-Gutierrez, GE Davies, J Shin… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

…, H Prokisch, W Rathmann, M Roden, S Sebert, J Shin… - Nature …, 2022 - nature.com
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 …

[HTML][HTML] Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis …

…, V Richarte, RJ Rose, J Shin… - Translational …, 2016 - nature.com
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide.
Occasional cannabis use can progress to frequent use, abuse and dependence with all …