[HTML][HTML] Staphylococcus aureus host interactions and adaptation
…, SL Baines, LK Sharkey, JYH Lee… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality, compounded
by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent …
by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent …
Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis
JYH Lee, IR Monk, A Gonçalves da Silva… - Nature …, 2018 - nature.com
Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely
present on healthy skin. Here we show that S. epidermidis has also evolved to become a …
present on healthy skin. Here we show that S. epidermidis has also evolved to become a …
Increasing tolerance of hospital Enterococcus faecium to handwash alcohols
Alcohol-based disinfectants and particularly hand rubs are a key way to control hospital
infections worldwide. Such disinfectants restrict transmission of pathogens, such as multidrug-…
infections worldwide. Such disinfectants restrict transmission of pathogens, such as multidrug-…
[HTML][HTML] Genomic Insights Into Last-Line Antimicrobial Resistance in Multidrug-Resistant Staphylococcus and Vancomycin-Resistant Enterococcus
Multidrug-resistant Staphylococcus and vancomycin-resistant Enterococcus (VRE) are
important human pathogens that are resistant to most clinical antibiotics. Treatment options are …
important human pathogens that are resistant to most clinical antibiotics. Treatment options are …
[HTML][HTML] Validation of a single-step, single-tube reverse transcription loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA
JYH Lee, N Best, J McAuley… - Journal of medical …, 2020 - microbiologyresearch.org
Introduction. The SARS-CoV-2 pandemic of 2020 has resulted in unparalleled requirements
for RNA extraction kits and enzymes required for virus detection, leading to global shortages…
for RNA extraction kits and enzymes required for virus detection, leading to global shortages…
[HTML][HTML] Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
…, SL Begg, M Gajdiss, LKR Sharkey, JYH Lee… - Nature …, 2019 - nature.com
WalKR (YycFG) is the only essential two-component regulator in the human pathogen
Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone does …
Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone does …
[HTML][HTML] Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic …
Staphylococcus aureus is a major cause of bovine mastitis, commonly leading to long-lasting,
persistent and recurrent infections. Thereby, S. aureus constantly refines and permanently …
persistent and recurrent infections. Thereby, S. aureus constantly refines and permanently …
Mining the methylome reveals extensive diversity in Staphylococcus epidermidis restriction modification
… characterized in this study and from publications by Lee et al. (12) and Costa et al. (11). …
sequence read archive (SRA), 75 isolates from a study by Lee et al. (5); and the 3 draft genomes …
sequence read archive (SRA), 75 isolates from a study by Lee et al. (5); and the 3 draft genomes …
Rifampicin resistance in Staphylococcus epidermidis: molecular characterisation and fitness cost of rpoB mutations
…, CL Brinkman, JYH Lee… - International Journal of …, 2018 - Elsevier
The molecular mechanisms and characteristics of rifampicin (RIF) resistance in Staphylococcus
epidermidis are poorly characterised, even though S. epidermidis is one of the most …
epidermidis are poorly characterised, even though S. epidermidis is one of the most …
[HTML][HTML] Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages
…, LM Cavaco, C Vingsbo Lundberg, JYH Lee… - Nature …, 2023 - nature.com
Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis
lineages underscores the need for new therapeutic strategies. Here we show that many S. …
lineages underscores the need for new therapeutic strategies. Here we show that many S. …