The elongated complementary-determining region (CDR) 3β found in the unliganded KB5-C20
TCR protrudes from the antigen binding site and prevents its docking onto the peptide/…

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and
pathological phenomena, yet its structural basis is poorly understood. We determined the crystal …

Many T cell receptors (TCRs) that are selected to respond to foreign peptide antigens bound
to self major histocompatibility complex (MHC) molecules are also reactive with allelic …

Protective T cell responses elicited along chronic human CMV (HCMV) infections are
sometimes dominated by CD8 T cell clones bearing highly related or identical public TCR in …

Peptidoglycan recognition proteins (PGRPs) form a recently discovered protein family, which
is conserved from insect to mammals and is implicated in the innate immune system by …

The alkyloid compound ellipticine derived from the berrywood tree is a topoisomerase II
poison that is used in ovarian and breast cancer treatment. In this study, we report the …

Protein kinase CK2 (casein kinase 2) is a eukaryotic serine/threonine protein kinase with
multiple substrates and roles in diverse cellular processes, including differentiation, proliferation…

Ficolins are soluble oligomeric proteins with lectin-like activity, assembled from collagen fibers
prolonged by fibrinogen-like recognition domains. They act as innate immune sensors by …

The immune system homeostasis relies on a tight equilibrium of interconnected stimulatory
and inhibitory signals. Disruption of this balance is characteristic of autoimmune diseases …

The di-allelic HLA-A2 restricted minor histocompatibility Ag HA-1 locus codes for the highly
immunogenic HA-1 His and the nonimmunogenic HA-1 Arg nonapeptides, differing in one …