Chromosomes of a broad range of species, from bacteria to mammals, are structured by
large topological domains whose precise functional roles and regulatory mechanisms remain …

Acquisition of cell fate is thought to rely on the specific interaction of remote cis-regulatory
modules (CRMs), for example, enhancers and target promoters. However, the precise …

Eukaryotic chromosomes are organized in multiple scales, from nucleosomes to
chromosome territories. Recently, genome-wide methods identified an intermediate level of …

Rho guanosine triphosphatases (GTPases) are master regulators of cell signaling, but how
they are regulated depending on the cellular context is unclear. We found that the …

At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting
modules or topologically associated domains (TADs) that associate to form nuclear …

Various rod-shaped bacteria mysteriously glide on surfaces in the absence of appendages
such as flagella or pili. In the deltaproteobacterium Myxococcus xanthus, a putative gliding …

Precise and rapid DNA segregation is required for proper inheritance of genetic material. In
most bacteria and archaea, this process is assured by a broadly conserved mitotic-like …

Cells maintain a constant dialog between the extracellular matrix and their plasma membrane
to fine tune signal transduction processes. We found that the receptor kinase FERONIA (…

Physiological acclimation of plants to an everchanging environment is governed by complex
combinatorial signaling networks that perceive and transduce various abiotic and biotic …

<p>ATP-fuelled molecular motors are responsible for rapid and specific transfer of double-stranded
DNA during several fundamental processes, such as cell division, sporulation, …