Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women
to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-…

Over the past 5 years there has been an explosion of new information on the physiological
and pathophysiological roles of NO within the heart as in other organ systems. In this review, …

Nitric oxide (NO) synthesized from L-arginine is a ubiquitous intracellular chemical messenger
and is involved in signal transduction in diverse mammalian cells, including vascular …

Beta1- and beta2-adrenoceptors in heart muscle cells mediate the catecholamine-induced
increase in the force and frequency of cardiac contraction. Recently, in addition, we …

The reductions in mortality and morbidity being achieved among cancer patients with current
therapies represent a major achievement. However, given their mechanisms of action, …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in cardiovascular
homeostasis. Tremendous knowledge has been accumulated on the mechanisms of …

Hypercholesterolemia is a central pathogenic factor of endothelial dysfunction caused in
part by an impairment of endothelial nitric oxide (NO) production through mechanisms that …

Cellular constituents of heart muscle contain both constitutive and inducible nitric oxide (NO)
signaling pathways that modulate the contractile properties of cardiac myocytes. The …

Background—Contrary to β 1 - and β 2 -adrenoceptors, β 3 -adrenoceptors mediate a negative
inotropic effect in human ventricular muscle. To assess their functional role in heart failure…

The increasing prevalence of heart failure poses enormous challenges for health care systems
worldwide. Despite effective medical interventions that target neurohumoral activation, …