A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused
by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to …

To further explore possible avenues for accessing microbial biodiversity for drug discovery
from natural products, we constructed and screened a 5,000-clone “shotgun” environmental …

Cyclodipeptides and their derivatives belong to the diketopiperazine (DKP) family, which is
comprised of a broad array of natural products that exhibit useful biological properties. In the …

The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium
tuberculosis. However, the CYP121 catalytic activity remains unknown. Here, we show that the …

The intrinsic resistance of the Mycobacterium tuberculosis complex (MTC) to most antibiotics,
including macrolides, is generally attributed to the low permeability of the mycobacterial …

Albonoursin [cyclo(ΔPhe-ΔLeu)], an antibacterial peptide produced by Streptomyces noursei,
is one of the simplest representatives of the large diketopiperazine (DKP) family. Formation …

Covering: up to 2012 We review here work on the biosynthesis of diketopiperazines (DKPs),
a large class of natural products with noteworthy biological activities, focusing on the …

Siderophore-mediated iron acquisition has been well studied in many bacterial pathogens
because it contributes to virulence. In contrast, siderophore-mediated iron acquisition by …

Three antibiotic resistance gene cassettes, derived from the π interposon (Prentki and Krisch
(1984) Gene 29, 303–313) were constructed. These cassettes carry different antibiotic …