β-Lactamases are the main cause of bacterial resistance to penicillins, cephalosporins and
related β-lactam compounds. These enzymes inactivate the antibiotics by hydrolysing the …

The efficiency of β‐lactam antibiotics, which are among our most useful chemotherapeutic
weapons, is continuously challenged by the emergence of resistant bacterial strains. This is …

During the past few years, several meetings were organized to celebrate the 50th anniversary
of Fleming’s historical discovery of penicillin. Reviews were written’-4 and books editeds-’…

Class A fl-lactamases fJ-Lactamases catalyse the hydrolysis of the fl-lactam ring of penicillins,
cephalosporins and related compounds, and thereby protect the bacteria which elaborate …

Metallo-β-lactamases constitute the molecular class B of Ambler (1) and group 3 according
to the Bush-Jacoby-Medeiros functional classification (6). In recent years, many new …

The 3‐D structure of Bacillus cereus (569/H/9) beta‐lactamase (EC 3.5.2.6), which catalyses
the hydrolysis of nearly all beta‐lactams, has been solved at 2.5 A resolution by the multiple …

We recently used a positional cloning approach to identify a nonconservative lysine to alanine
substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative …

-Lactamases represent the major cause of bacterial resistance against-lactam antibiotics,
and they have been divided into four classes (A to D) on the basis of their amino acid …

β-lactam induction of chromosomal β-lactamase in gram-negative bacteria requires the
transcriptional regulator AmpR and the transport of murein breakdown products (muropeptides) …

Small, soluble single-domain fragments derived from the unique variable region of dromedary
heavy-chain antibodies (VHHs) against enzymes are known to be potent inhibitors. The …