Local translation regulates the axonal proteome, playing an important role in neuronal wiring
and axon maintenance. How axonal mRNAs are localized to specific subcellular sites for …

Nascent proteins can be positioned rapidly at precise subcellular locations by local protein
synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major …

Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust
enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far …

… Author links open overlay panel Jean-Michel Cioni 1 , Max Koppers 1 , Christine E Holt …
Strohl, CG Roque, JM Cioni, R. Cagnetta, B. Turner-Bridger, RF Laine, WA Harris, CF Kaminski, …

Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …

Subcellular target recognition in the CNS is the culmination of a multiple-step program including
axon guidance, target recognition, and synaptogenesis. In cerebellum, basket cells (BCs…

… In this paper, Cioni et al. reveal new insights on how retinal axons segregate in the optic …
Jean-Michel Cioni,1 Hovy Ho-Wai Wong,1 Dario Bressan,2 Lay Kodama,1 William A. Harris,1 …

Background GABAergic interneurons regulate the balance and dynamics of neural circuits,
in part, by elaborating their strategically placed axon branches that innervate specific cellular …

Within the chromatin, distal elements interact with promoters to regulate specific transcriptional
programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a …

During amniote peripheral nervous system development, segmentation ensures the correct
patterning of the spinal nerves relative to the vertebral column. Along the antero-posterior (…