We report Ca 2+ -induced release of Ca 2+ from mitochondria (mCICR) dependent on transitory
opening of the permeability transition pore (PTP) operating in a low conductance mode. …

The study of mitochondrial diseases has revealed dramatic variability in the phenotypic
presentation of mitochondrial genetic defects. To attempt to understand this variability, different …

The permeability transition pore (PTP) is a channel of the inner mitochondrial membrane
that appears to operate at the crossroads of two distinct physiological pathways, ie, the Ca 2+ …

Mitochondrial cytopathies present a tissue specificity characterized by the fact that even if a
mitochondrial DNA mutation is present in all tissues, only some will be affected and induce a …

Background High lipophilic local anesthetics interfere with mitochondrial energy metabolism.
These metabolic effects could in part explain some of the toxic effects of local anesthetics, …

Diversity of respiratory chain spectrophotometric assays may lead to difficult comparison of
results between centers. The French network of mitochondrial diseases diagnostic centers …

Metabolic control analysis has often been used for quantitative studies of the regulation of
mitochondrial oxidative phosphorylations (OXPHOS). The main contribution of this work has …

The respiratory chain is located in the inner membrane of mitochondria and produces the
major part of the ATP used by a cell. Cardiolipin (CL), a double charged phospholipid …

ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules
and strong oxidizing agents leading to oxidative stress. Their production mainly occurs in …

To assess the influence of the environment on fruit metabolism, tomato (Solanum lycopersicum
‘Moneymaker’) plants were grown under contrasting conditions (optimal for commercial, …