Drugs of abuse, such as psychostimulants and opiates, are generally considered as exerting
their locomotor and rewarding effects through an increased dopaminergic transmission in …

A challenge in drug dependence is to delineate long-term behavioral and neurochemical
modifications induced by drugs of abuse. In rodents, drugs of abuse induce locomotor …

Repeated traumatic events induce long-lasting behavioral changes that are key to organism
adaptation and that affect cognitive, emotional, and social behaviors. Rodents subjected to …

The locomotor hyperactivity induced by systemic or local (nucleus accumbens) d-amphetamine
injections can be blocked by systemic or local (prefrontal cortex) injections of prazosin, …

Addictive properties of drugs of misuse are generally considered to be mediated by an
increased release of dopamine (DA) in the ventral striatum. However, recent experiments …

Bilateral high frequency lesions of the ventral tegmental area (VTA) in the rat induce a
behavioral syndrome characterized by a permanent locomotor hyperactivity and a reduction of …

The effects of electrical foot shock on the activity of the ascending dopaminergic neurons were
estimated in the rat by measuring the changes in DOPAC and DA levels in discrete brain …

In rodents, drugs of abuse induce locomotor hyperactivity, and repeating injections enhances
this response. This effect, called behavioral sensitization, persists many months after the …

Although nicotine is generally considered to be the main compound responsible for the
addictive properties of tobacco, experimental data indicate that nicotine does not exhibit all the …

Psychostimulant‐induced locomotor hyperactivity is commonly associated with an inhibition
of dopamine reuptake. However, a physiological coupling between noradrenergic and …