User profiles for Jean-Sébastien Rougier

Jean-Sebastien Rougier

Senior Teaching and Research assistant, Universitiy of Bern, Switzerland
Verified email at ibmm.unibe.ch
Cited by 2811

Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin

B Gavillet, JS Rougier, AA Domenighetti… - Circulation …, 2006 - Am Heart Assoc
The cardiac sodium channel Na v 1.5 plays a key role in cardiac excitability and conduction.
The purpose of this study was to elucidate the role of the PDZ domain-binding motif formed …

Cardiac Voltage-Gated Sodium Channel Nav1.5 Is Regulated by Nedd4-2 Mediated Ubiquitination

MX van Bemmelen, JS Rougier, B Gavillet… - Circulation …, 2004 - Am Heart Assoc
Na v 1.5, the cardiac isoform of the voltage-gated Na + channel, is critical to heart excitability
and conduction. However, the mechanisms regulating its expression at the cell membrane …

Brugada syndrome and fever: Genetic and molecular characterization of patients carrying SCN5A mutations

DI Keller, JS Rougier, JP Kucera… - Cardiovascular …, 2005 - academic.oup.com
Objective: Brugada syndrome (BrS) is characterized by ventricular tachyarrhythmias leading
to sudden cardiac death and is caused, in part, by mutations in the SCN5A gene encoding …

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

JS Rougier, MX van Bemmelen… - … of Physiology-Cell …, 2005 - journals.physiology.org
The voltage-gated Na + channels (Na v ) form a family composed of 10 genes. The COOH
termini of Na v contain a cluster of amino acids that are nearly identical among 7 of the 10 …

Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death

H Abriel, JS Rougier, J Jalife - Circulation research, 2015 - Am Heart Assoc
The movement of ions across specific channels embedded on the membrane of individual
cardiomyocytes is crucial for the generation and propagation of the cardiac electric impulse. …

PDZ Domain–Binding Motif Regulates Cardiomyocyte Compartment-Specific NaV1.5 Channel Expression and Function

…, M Albesa, AO Verkerk, R Wolswinkel, JS Rougier… - Circulation, 2014 - Am Heart Assoc
Background— Sodium channel Na V 1.5 underlies cardiac excitability and conduction. The
last 3 residues of Na V 1.5 (Ser-Ile-Val) constitute a PDZ domain–binding motif that interacts …

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

C Templin, JR Ghadri, JS Rougier… - European heart …, 2011 - academic.oup.com
Aims Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which
may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five …

TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology

…, N Syam, V Sottas, MY Amarouch, JS Rougier - Biochemical …, 2012 - Elsevier
The transient receptor potential channel (TRP) family comprises at least 28 genes in the
human genome. These channels are widely expressed in many different tissues, including …

Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes

…, A Beuriot, MYE Chevalier, JS Rougier… - Circulation …, 2016 - Am Heart Assoc
Rationale: Mechanisms underlying membrane protein localization are crucial in the proper
function of cardiac myocytes. The main cardiac sodium channel, Na V 1.5, carries the sodium …

[HTML][HTML] Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a+/− Mouse Model

AL Leoni, B Gavillet, JS Rougier, C Marionneau… - PloS one, 2010 - journals.plos.org
Background Loss-of-function mutations in SCN5A, the gene encoding Na v 1.5 Na + channel,
are associated with inherited cardiac conduction defects and Brugada syndrome, which …