User profiles for Jeanne Savage
JE SavageVrije Universiteit Amsterdam Verified email at vu.nl Cited by 7584 |
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms
Objective Little is known about the longitudinal genetic and environmental association
between juvenile irritability and symptoms of anxiety and depression. This study’s goal was to …
between juvenile irritability and symptoms of anxiety and depression. This study’s goal was to …
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Neuroticism is an important risk factor for psychiatric traits, including depression 1 , anxiety 2
, 3 , and schizophrenia 4 , 5 – 6 . At the time of analysis, previous genome-wide association …
, 3 , and schizophrenia 4 , 5 – 6 . At the time of analysis, previous genome-wide association …
Psychosocial and contextual determinants of alcohol and drug use disorders in the National Latino and Asian American Study
Background In the US, Latino and Asian American immigrants and ethnic minorities may be
at increased risk for alcohol and drug use disorders (AUDs/DUDs). The role of psychosocial …
at increased risk for alcohol and drug use disorders (AUDs/DUDs). The role of psychosocial …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Insomnia is the second most prevalent mental disorder, with no sufficient treatment available.
Despite substantial heritability, insight into the associated genes and neurobiological …
Despite substantial heritability, insight into the associated genes and neurobiological …
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome. …
cognitive impairment, which is considered a major determinant of functional outcome. …
Internalizing and externalizing subtypes of alcohol misuse and their relation to drinking motives
Background Several typologies have proposed two etiological pathways involved in the
development of alcohol misuse which are associated with the internalizing and externalizing …
development of alcohol misuse which are associated with the internalizing and externalizing …