Understanding how eukaryotic enhancers are bound and regulated by specific combinations
of transcription factors is still a major challenge. To better map transcription factor binding …

The Drosophila genome activator Vielfaltig (Vfl), also known as Zelda (Zld), is thought to
prime enhancers for activation by patterning transcription factors (TFs). Such priming is …

10.7554/eLife.00861.001 Massive zygotic transcription begins in many organisms during the
midblastula transition when the cell cycle of the dividing egg slows down. A few genes are …

… the trial: Jeffrey Johnston and Bernard Lavins; assisted in the interpretation of data and
critical revision of the manuscript for important intellectual content: Jeffrey Johnston, Bernard …

Without exception, the most complex organic architectures have been produced by natural
organisms. The finding that many of these can be both selective and potent disruptors of …

Study Design: Case-control, cross-sectional, and cohort studies that examined the
association between HIV seroconversion and GUD were chosen from the literature. Twenty-seven …

OBJECTIVES: Linaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective
of this trial was to determine the efficacy and safety of linaclotide in patients with irritable …

Despite Nature's longstanding ability to use a proton, the most prevalent Lewis acid, to both
activate and orient a substrate during an enantioselective reaction, this work represents the …

Background Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C
receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients …

The binding of some transcription factors has been shown to diverge substantially between
closely related species. Here we show that the binding of the developmental transcription …