Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes
…, R Misra, H Huyck, L Rogers, C Poole, JA Whitsett… - Elife, 2020 - elifesciences.org
Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-…
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-…
Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease
Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent
hypoxia (IH) and is associated with a host of health complications. Although the lung is the first …
hypoxia (IH) and is associated with a host of health complications. Although the lung is the first …
Single nucleus multiomic profiling reveals age-dynamic regulation of host genes associated with SARS-CoV-2 infection
…, R Misra, H Huyck, L Rogers, C Poole, JA Whitsett… - Biorxiv, 2020 - biorxiv.org
Respiratory failure is the leading cause of COVID-19 death and disproportionately impacts
adults more than children. Here, we present a large-scale snATAC-seq dataset (90,980 nuclei…
adults more than children. Here, we present a large-scale snATAC-seq dataset (90,980 nuclei…
Fetal monkey surfactants after intra-amniotic or maternal administration of betamethasone and thyroid hormone
WM Gilbert, E Eby-Wilkens, C Plopper, JA Whitsett… - Obstetrics & …, 2001 - Elsevier
OBJECTIVE: To compare direct intra-amniotic injection of betamethasone and thyroxine (T4)
with maternal treatment and controls for accelerating pulmonary surfactant production. …
with maternal treatment and controls for accelerating pulmonary surfactant production. …
Lamellar body formation precedes pulmonary surfactant apoprotein expression during embryonic mouse lung development in vivo and in vitro
…, P Bringas Jr, G Don-Wheeler, M Mayo, JA Whitsett… - Differentiation, 1989 - Elsevier
The purpose of this investigation was to determine whether lamellar inclusion body (LB)
formation and surfactant apoprotein (SP-35) production are directly coordinated by temporal …
formation and surfactant apoprotein (SP-35) production are directly coordinated by temporal …
Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A
…, TR Korfhagen, JA Whitsett… - Journal of Applied …, 2002 - journals.physiology.org
Surfactant alterations, alveolar cytokine changes, and the role of surfactant protein (SP)-A in
septic mice were investigated. Sepsis was induced via cecal ligation and perforation (CLP). …
septic mice were investigated. Sepsis was induced via cecal ligation and perforation (CLP). …
Increased Granulocyte Macrophage–Colony Stimulating Factor Concentration in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Alveolar Proteinosis
RP Baughman, D Romberger, JA Whitsett… - … of Bronchology & …, 2002 - journals.lww.com
Pulmonary alveolar proteinosis (PAP) is a rare disease that had been treated by whole-lung
lavage. Recent reports of success in treating alveolar proteinosis with granulocyte …
lavage. Recent reports of success in treating alveolar proteinosis with granulocyte …
Development of a novel targeted therapy for malignant mesothelioma carcinoma by a midkine inhibitor
…, M Haisa, N Miyake, T Ikeda, N Takigawa, J Whitsett… - Cancer Research, 2017 - AACR
Malignant pleural mesothelioma is an aggressive tumor of mesenchymal origin and is
increasing worldwide as a result of widespread exposure to asbestos. The median survival of …
increasing worldwide as a result of widespread exposure to asbestos. The median survival of …
Abnormal Lamellar Body Formation in SP-B Deficient Mice• 308
MT Stahlman, ME Gray, JA Whitsett, TE Weaver - Pediatric Research, 1998 - nature.com
Congenital surfactant associated protein B deficiency is now a recognized clinical and
pathological entity. In order to better understand the pathogenesis of the pulmonary disorder, we …
pathological entity. In order to better understand the pathogenesis of the pulmonary disorder, we …
[HTML][HTML] TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury
Extracellular matrix production and accumulation stabilize the heart under normal conditions
as well as form a protective scar after myocardial infarction injury, although excessive …
as well as form a protective scar after myocardial infarction injury, although excessive …