Evolutionary and biomedical insights from the rhesus macaque genome

…, JE Karro, J Ma, B Raney, X She, MJ Cox, JP Demuth… - science, 2007 - science.org
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …

[PDF][PDF] The genome of the model beetle and pest Tribolium castaneum.

…, P Arensburger, P Atkinson, J Beidler, JP Demuth… - Nature, 2008 - serval.unil.ch
Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model
organism for the study of generalized insect development, and an important pest of stored …

CAFE: a computational tool for the study of gene family evolution

T De Bie, N Cristianini, JP Demuth, MW Hahn - Bioinformatics, 2006 - academic.oup.com
We present CAFE (Computational Analysis of gene Family Evolution), a tool for the statistical
analysis of the evolution of the size of gene families. It uses a stochastic birth and death …

[HTML][HTML] The evolution of mammalian gene families

JP Demuth, TD Bie, JE Stajich, N Cristianini, MW Hahn - PloS one, 2006 - journals.plos.org
Gene families are groups of homologous genes that are likely to have highly similar functions.
Differences in family size due to lineage-specific gene duplication and gene loss may …

The life and death of gene families

JP Demuth, MW Hahn - Bioessays, 2009 - Wiley Online Library
One of the unique insights provided by the growing number of fully sequenced genomes is
the pervasiveness of gene duplication and gene loss. Indeed, several metrics now suggest …

[HTML][HTML] Genome of the Asian longhorned beetle (Anoplophora glabripennis), a globally significant invasive species, reveals key functional and evolutionary …

…, C Childers, DJ Clarke, L Cohen, JP Demuth… - Genome biology, 2016 - Springer
Background Relatively little is known about the genomic basis and evolution of wood-feeding
in beetles. We undertook genome sequencing and annotation, gene expression assays, …

Adaptive evolution of young gene duplicates in mammals

MV Han, JP Demuth, CL McGrath, C Casola… - Genome …, 2009 - genome.cshlp.org
Duplicate genes act as a source of genetic material from which new functions arise. They
exist in large numbers in every sequenced eukaryotic genome and may be responsible for …

Accelerated rate of gene gain and loss in primates

MW Hahn, JP Demuth, SG Han - Genetics, 2007 - academic.oup.com
The molecular changes responsible for the evolution of modern humans have primarily
been discussed in terms of individual nucleotide substitutions in regulatory or protein coding …

The origins and evolution of chromosomes, dosage compensation, and mechanisms underlying venom regulation in snakes

…, AB Corbin, CF Smith, B Ramesh, JP Demuth… - Genome …, 2019 - genome.cshlp.org
Here we use a chromosome-level genome assembly of a prairie rattlesnake (Crotalus viridis),
together with Hi-C, RNA-seq, and whole-genome resequencing data, to study key features …

Haldane's rule: genetic bases and their empirical support

LF Delph, JP Demuth - Journal of Heredity, 2016 - academic.oup.com
There are few patterns in evolution that are as rigidly held as Haldane’s rule (HR), which
states, “When in the first generation between hybrids between 2 species, 1 sex is absent, rare, …