Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Genome-wide association studies have identified 32 loci influencing body mass index, but
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-…
this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-…
Physical activity and the association of common FTO gene variants with body mass index and obesity
…, TI Pollin, M Fu, H Shen, JR O'Connell… - Archives of internal …, 2008 - jamanetwork.com
Background CommonFTO(fat mass and obesity associated) gene variants have recently
been associated with body mass index (BMI) and obesity in several large studies. The role of …
been associated with body mass index (BMI) and obesity in several large studies. The role of …
[PDF][PDF] Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci
…, CP Nelson, SJ Newhouse, JR O'Connell… - The American Journal of …, 2012 - cell.com
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe …
meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe …
[PDF][PDF] Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
…, K Musunuru, CP Nelson, JR O'Connell… - The American Journal of …, 2012 - cell.com
Genome-wide association studies (GWASs) have identified many SNPs underlying
variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid …
variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid …
[PDF][PDF] Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci
…, M Kumari, W März, SS Murray, JR O'Connell… - The American Journal of …, 2014 - cell.com
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate
genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), …
genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), …
Loci influencing blood pressure identified using a cardiovascular gene-centric array
…, C Newton-Cheh, JR O'Connell… - Human molecular …, 2013 - academic.oup.com
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To
investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial …
investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial …
[HTML][HTML] Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank
RJ Scalsky, YJ Chen, K Desai, JR O'Connell… - PLoS …, 2021 - journals.plos.org
Background SARS-CoV-2 is a rapidly spreading coronavirus responsible for the Covid-19
pandemic, which is characterized by severe respiratory infection. Many factors have been …
pandemic, which is characterized by severe respiratory infection. Many factors have been …
Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish
…, YPC Chang, MR Weir, JR O'Connell… - Arthritis & …, 2008 - Wiley Online Library
Objective Uric acid is the primary end product of purine metabolism. Increased serum uric
acid levels have been associated with gouty arthritis as well as with a variety of cardiovascular…
acid levels have been associated with gouty arthritis as well as with a variety of cardiovascular…
Association of the Vitamin D Metabolism Gene CYP24A1 With Coronary Artery Calcification
…, J Liu, W Post, JR O'Connell… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—The vitamin D endocrine system is essential for calcium homeostasis, and low
levels of vitamin D metabolites have been associated with cardiovascular disease risk. We …
levels of vitamin D metabolites have been associated with cardiovascular disease risk. We …
[HTML][HTML] Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
…, AU Jackson, ME Montasser, JR O'Connell… - Nature …, 2021 - nature.com
Differences between sexes contribute to variation in the levels of fasting glucose and insulin.
Epidemiological studies established a higher prevalence of impaired fasting glucose in …
Epidemiological studies established a higher prevalence of impaired fasting glucose in …