Protein secretion is a common property of pathogenic microbes. Gram-negative bacterial
pathogens use at least 6 distinct extracellular protein secretion systems to export proteins …

The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at
2.6 Å resolution. PABP recognizes the 3′ mRNA poly(A) tail and plays critical roles in …

With access to whole genome sequences for various organisms and imminent completion
of the Human Genome Project, the entire process of discovery in molecular and cellular …

Elimination of nonnutritional and insoluble compounds is a critical task for any living
organism. Flavin-containing monooxygenases (FMOs) attach an oxygen atom to the insoluble …

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS
Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure …

The arginine methyltransferase PRMT5-MEP50 is required for embryogenesis and is
misregulated in many cancers. PRMT5 targets a wide variety of substrates, including histone …

Rational modulation of the immune response with biologics represents one of the most
promising and active areas for the realization of new therapeutic strategies. In particular, the use …

Sactipeptides are ribosomally synthesized peptides that contain a characteristic thioether
bridge (sactionine bond) that is installed posttranslationally and is absolutely required for their …

Ipilimumab, a monoclonal antibody that recognizes cytotoxic T lymphocyte antigen (CTLA)-4,
was the first approved “checkpoint”-blocking anticancer therapy. In mouse tumor models, …

Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive cancer immunotherapeutic
target owing to its role in promoting tumoral immune escape. However, drug development …