Estrogens influence the differentiation and maintenance of reproductive tissues and affect
lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified to …

An abnormal neutrophil subset has been identified in the PBMC fractions from lupus patients.
We have proposed that these low-density granulocytes (LDGs) play an important role in …

To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension,
mice were generated with a disruption of the proANP gene. Homozygous mutants had no …

ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that
generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide …

Variants of the human angiotensinogen gene have been linked in some studies to increased
circulating angiotensinogen levels and essential hypertension. To test for direct causality …

We have validated a noninvasive computerized tail-cuff system for measuring blood pressure
in mice. The system was designed to perform all functions automatically, including a …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods 1 . Here we …

Objectives An imbalance between neutrophil extracellular trap (NET) formation and degradation
has been described in systemic lupus erythematosus (SLE), potentially contributing to …

Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates
plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose …

Background and objectives: Low birth weight (LBW), resulting from intrauterine growth retardation
(IUGR) or prematurity, is a risk factor for adult hypertension and chronic kidney disease…