Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure
Background— The failing human heart is characterized by metabolic abnormalities, but
these defects remains incompletely understood. In animal models of heart failure there is a …
these defects remains incompletely understood. In animal models of heart failure there is a …
[HTML][HTML] Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
…, ML Biggs, HL Bloom, J Brandimarto… - Nature …, 2020 - nature.com
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
…, R Insolia, RM Hamilton, SW Scherer, J Brandimarto… - Nature …, 2014 - nature.com
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …
[HTML][HTML] RNA-Seq identifies novel myocardial gene expression signatures of heart failure
Heart failure is a complex clinical syndrome and has become the most common reason for
adult hospitalization in developed countries. Two subtypes of heart failure, ischemic heart …
adult hospitalization in developed countries. Two subtypes of heart failure, ischemic heart …
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …
Thyroid dysfunction in heart failure and cardiovascular outcomes
Background: The effects of thyroid dysfunction in patients with preexisting heart failure have
not been adequately studied. We examined the prevalence of thyroid dysfunction and …
not been adequately studied. We examined the prevalence of thyroid dysfunction and …
Genetic and phenotypic landscape of peripartum cardiomyopathy
R Goli, J Li, J Brandimarto, LD Levine, V Riis… - Circulation, 2021 - Am Heart Assoc
Background: Peripartum cardiomyopathy (PPCM) occurs in ≈1:2000 deliveries in the
United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. …
United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. …
Truncated titin proteins in dilated cardiomyopathy
Truncating variants in TTN (TTNtvs) are the most common known cause of nonischemic
dilated cardiomyopathy (DCM), but how TTNtvs cause disease has remained controversial. …
dilated cardiomyopathy (DCM), but how TTNtvs cause disease has remained controversial. …
[PDF][PDF] An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval
QT interval variation is assumed to arise from variation in repolarization as evidenced from
rare Na- and K-channel mutations in Mendelian QT prolongation syndromes. However, in the …
rare Na- and K-channel mutations in Mendelian QT prolongation syndromes. However, in the …
Tunable and reversible substrate stiffness reveals a dynamic mechanosensitivity of cardiomyocytes
…, EG Peyster, M Bhoopalam, J Brandimarto… - … applied materials & …, 2019 - ACS Publications
New directions in material applications have allowed for the fresh insight into the coordination
of biophysical cues and regulators. Although the role of the mechanical microenvironment …
of biophysical cues and regulators. Although the role of the mechanical microenvironment …