User profiles for Jeffrey C. Medley
Jeffrey C MedleyKansas State University Verified email at ksu.edu Cited by 220 |
microRNA strand selection: Unwinding the rules
microRNAs (miRNAs) play a central role in the regulation of gene expression by targeting
specific mRNAs for degradation or translational repression. Each miRNA is post‐…
specific mRNAs for degradation or translational repression. Each miRNA is post‐…
[HTML][HTML] ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics
Centrosomes are critical sites for orchestrating microtubule dynamics, and exhibit dynamic
changes in size during the cell cycle. As cells progress to mitosis, centrosomes recruit more …
changes in size during the cell cycle. As cells progress to mitosis, centrosomes recruit more …
APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans
JC Medley, LE DeMeyer, MM Kabara… - G3: Genes, Genomes …, 2017 - academic.oup.com
As the primary microtubule-organizing center, centrosomes play a key role in establishing
mitotic bipolar spindles that secure correct transmission of genomic content. For the fidelity of …
mitotic bipolar spindles that secure correct transmission of genomic content. For the fidelity of …
Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos
JC Medley, MM Kabara, MD Stubenvoll… - Biology …, 2017 - journals.biologists.com
Centrosomes are the primary microtubule-organizing centers that orchestrate microtubule
dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing …
dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing …
APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number
JC Medley, JR DiPanni, L Schira… - Journal of cell …, 2021 - journals.biologists.com
Aberrant centrosome numbers are associated with human cancers. The levels of centrosome
regulators positively correlate with centrosome number. Thus, tight control of centrosome …
regulators positively correlate with centrosome number. Thus, tight control of centrosome …
[PDF][PDF] Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number
JC Medley, RN Yim, J DiPanni, B Sebou, B Shaffou… - Iscience, 2023 - cell.com
Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates
bipolarity, tight control of centrosome assembly is vital for faithful cell division. The master …
bipolarity, tight control of centrosome assembly is vital for faithful cell division. The master …
Single nucleotide substitutions effectively block Cas9 and allow for scarless genome editing in Caenorhabditis elegans
In Caenorhabditis elegans, germline injection of Cas9 complexes is reliably used to achieve
genome editing through homology-directed repair of Cas9-generated DNA breaks. To …
genome editing through homology-directed repair of Cas9-generated DNA breaks. To …
[HTML][HTML] kin-3 genetically suppresses sur-6 in centrosome assembly during Caenorhabditis elegans embryogenesis
Protein phosphorylation plays a critical role in cell cycle progression. In Caenorhabditis
elegans, Casein Kinase II (CK2) negatively regulates centrosome assembly, and Protein …
elegans, Casein Kinase II (CK2) negatively regulates centrosome assembly, and Protein …
[HTML][HTML] The C. elegans Casein Kinase II is associated with meiotic DNA in fertilized oocytes
By using CRISPR/Cas9 genome-editing, we have generated epitope-tagged KIN-3 and KIN-10
expressing strains at the endogenous C-terminal loci in Caenorhabditis elegans. We …
expressing strains at the endogenous C-terminal loci in Caenorhabditis elegans. We …
Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics
The reference for the origin of the strain WM210 is missing in S1 Table. The reference is:
Gnazzo MM, Uhlemann EM, Villarreal AR, Shirayama M, Dominguez EG, Skop AR. The RNA-…
Gnazzo MM, Uhlemann EM, Villarreal AR, Shirayama M, Dominguez EG, Skop AR. The RNA-…