User profiles for Jeffrey C. Medley

Jeffrey C Medley

Kansas State University
Verified email at ksu.edu
Cited by 220

microRNA strand selection: Unwinding the rules

JC Medley, G Panzade… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
microRNAs (miRNAs) play a central role in the regulation of gene expression by targeting
specific mRNAs for degradation or translational repression. Each miRNA is post‐…

[HTML][HTML] ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics

MD Stubenvoll, JC Medley, M Irwin, MH Song - PLoS genetics, 2016 - journals.plos.org
Centrosomes are critical sites for orchestrating microtubule dynamics, and exhibit dynamic
changes in size during the cell cycle. As cells progress to mitosis, centrosomes recruit more …

APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans

JC Medley, LE DeMeyer, MM Kabara… - G3: Genes, Genomes …, 2017 - academic.oup.com
As the primary microtubule-organizing center, centrosomes play a key role in establishing
mitotic bipolar spindles that secure correct transmission of genomic content. For the fidelity of …

Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditiselegans embryos

JC Medley, MM Kabara, MD Stubenvoll… - Biology …, 2017 - journals.biologists.com
Centrosomes are the primary microtubule-organizing centers that orchestrate microtubule
dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing …

APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number

JC Medley, JR DiPanni, L Schira… - Journal of cell …, 2021 - journals.biologists.com
Aberrant centrosome numbers are associated with human cancers. The levels of centrosome
regulators positively correlate with centrosome number. Thus, tight control of centrosome …

[PDF][PDF] Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number

JC Medley, RN Yim, J DiPanni, B Sebou, B Shaffou… - Iscience, 2023 - cell.com
Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates
bipolarity, tight control of centrosome assembly is vital for faithful cell division. The master …

Single nucleotide substitutions effectively block Cas9 and allow for scarless genome editing in Caenorhabditis elegans

JC Medley, S Hebbar, JT Sydzyik, AY Zinovyeva - Genetics, 2022 - academic.oup.com
In Caenorhabditis elegans, germline injection of Cas9 complexes is reliably used to achieve
genome editing through homology-directed repair of Cas9-generated DNA breaks. To …

[HTML][HTML] kin-3 genetically suppresses sur-6 in centrosome assembly during Caenorhabditis elegans embryogenesis

JC Medley, MH Song - Micropublication Biology, 2023 - ncbi.nlm.nih.gov
Protein phosphorylation plays a critical role in cell cycle progression. In Caenorhabditis
elegans, Casein Kinase II (CK2) negatively regulates centrosome assembly, and Protein …

[HTML][HTML] The C. elegans Casein Kinase II is associated with meiotic DNA in fertilized oocytes

N Yim, JC Medley, MH Song - Micropublication Biology, 2022 - ncbi.nlm.nih.gov
By using CRISPR/Cas9 genome-editing, we have generated epitope-tagged KIN-3 and KIN-10
expressing strains at the endogenous C-terminal loci in Caenorhabditis elegans. We …

Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics

MD Stubenvoll, JC Medley, M Irwin, MH Song - PLoS genetics, 2016 - journals.plos.org
The reference for the origin of the strain WM210 is missing in S1 Table. The reference is:
Gnazzo MM, Uhlemann EM, Villarreal AR, Shirayama M, Dominguez EG, Skop AR. The RNA-…