Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …

A growing body of evidence indicates that many cellular reactions within metabolic pathways
are catalyzed not by free-floating ‘soluble’ enzymes, but via one or more membrane-…

The role that mechanistic mathematical modeling and systems biology will play in molecular
medicine and clinical development remains uncertain. In this study, mathematical modeling …

The ubiquitin-proteasome pathway (UPP) is the main route of protein degradation in
eukaryotic cells and is a common mechanism through which numerous cellular pathways are …

Both physiological and pathological tissue remodeling (eg, during wound healing and
cancer, respectively) require new blood vessel formation via angiogenesis, but the underlying …

Cell-free systems for gene expression have gained attention as platforms for the facile study
of genetic circuits and as highly effective tools for teaching. Despite recent progress, the …

In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced
differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA-inducible …

A major objective of synthetic glycobiology is to re-engineer existing cellular glycosylation
pathways from the top down or construct non-natural ones from the bottom up for new and …

RNA genetic circuitry is emerging as a powerful tool to control gene expression. However,
little work has been done to create a theoretical foundation for RNA circuit design. A …

Cell-free protein synthesis (CFPS) is a widely used research tool in systems and synthetic
biology. However, if CFPS is to become a mainstream technology for applications such as …