SIRT1 (Sir2) is an NAD + -dependent deacetylase that plays critical roles in a broad range of
biological events, including metabolism, the immune response and ageing 1 , 2 , 3 , 4 – 5 . …

The construction of multiple carbon-carbon bonds in a single chemical step represents a
particularly efficient approach to the synthesis of complex molecular structures. 1 Dramatic …

Autophagy is a lysosome-dependent degradative process that protects cancer cells from
multiple stresses. In preclinical models, autophagy inhibition with chloroquine (CQ) derivatives …

The emergence of drug-resistant bacteria has compromised the use of many conventional
antibiotics, leading to heightened interest in a variety of antimicrobial peptides. Although …

Deregulation of the cell cycle machinery is a hallmark of cancer. While CDK4/6 inhibitors are
FDA approved (palbociclib) for treating advanced estrogen receptor-positive breast cancer, …

Due in large measure to its promising biological activity and unique mechanism of action,
the syn-thesis of the structurally complex naturally occurring antitumor agent taxoi (5) has …

We report herein the synthesis and spectroscopic study of the first spiropyrandinolines that
function as sensors for metal ions in the parts per billion range. These systems operate by …

… We reasoned that the incorporation of heteroatom functionality at C-14 (ingenol numbering)
in 10 would facilitate the introduction of the ingenol D-ring cyclopropane via Δ 13,14 olefin …

This study identifies PPT1 as the previously unknown lysosomal molecular target of monomeric
and dimeric CQ derivatives. Genetic suppression of PPT1 impairs tumor growth, and …

Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (ie, autophagy
and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial …