How do the key features of protein folding, elucidated from studies on native, isolated proteins,
manifest in cotranslational folding on the ribosome? Using a well-characterized family of …

Proteins that fold cotranslationally may do so in a restricted configurational space, due to
the volume occupied by the ribosome. How does this environment, coupled with the close …

Recent in silico analysis has revealed the presence of a group of proteins in pro and lower
eukaryotes, but not in Man, that show extensive amino acid sequence similarity to known O 6 -…

Determining the relationship between protein folding pathways on and off the ribosome
remains an important area of investigation in biology. Studies on isolated domains have shown …

The BCL-2 family of proteins plays a central role in regulating cell survival and apoptosis.
Disordered BH3-only proteins bind promiscuously to a number of different BCL-2 proteins, with …

The rugged folding landscapes of functional proteins puts them at risk of misfolding and
aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance …

Phosphorylation is a ubiquitous protein post-translational modification, and the importance of
phosphorylation of serine, threonine and tyrosine is well established. What is lesser known …

Background Dry needling treatment focuses on restoring normal muscle function in patients
with musculoskeletal pain; however, little research has investigated this assertion. Shear …

We report herein the study of Förster resonance energy transfer (FRET) between a CdSe/ZnS
core/shell quantum dot (QD) capped with three different small-molecule ligands, 3-…

Attempting to retrieve the answer to a question on an initial test can improve memory for that
answer on a subsequent test, relative to an equivalent study period. Such retrieval attempts …