Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be annotated …

The biological interpretation of gene lists with interesting shared properties, such as up-or
down-regulation in a particular experiment, is typically accomplished using gene ontology …

Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …

The Structure–Function Linkage Database (SFLD, http://sfld.rbvi.ucsf.edu/ ) is a manually
curated classification resource describing structure–function relationships for functionally …

Motivation Critical evaluation of methods for protein function prediction shows that data
integration improves the performance of methods that predict protein function, but a basic BLAST-…

Prediction of protein function continues to be an active area of research. While the performance
of automated function prediction methods continues to improve, assessments of their …

Importance The US is currently an epicenter of the coronavirus disease 2019 (COVID-19)
pandemic, yet few national data are available on patient characteristics, treatment, and …

Importance Therapies that improve survival in critically ill patients with coronavirus disease
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …

… m 2 , respectively, compared with eGFR > 60 mL/min/1.73 m 2 . Oliguria at the time of KRT
initiation was also associated with nonrecovery (ORs of 2.10 [95% CI, 1.14-3.88] and 4.02 [95…

Pretreatment evaluation is performed to determine the number, location, and size of the
brain metastases and magnetic resonance imaging (MRI) is the recommended imaging …