The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we
demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress the …

The focus of the present study was to define the human plasma lipidome and to establish
novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid …

Animal cells control their membrane lipid composition within narrow limits, but the sensing
mechanisms underlying this control are largely unknown. Recent studies disclosed a protein …

Inflammation and macrophage foam cells are characteristic features of atherosclerotic
lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-…

Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc
stimulates glutamine metabolism and renders cells dependent on glutamine to sustain …

Type I interferon (IFN) protects against viruses, yet it also has a poorly understood suppressive
influence on inflammation. Here, we report that activated mouse macrophages lacking …

The liver X receptors (LXRs) are ligand-activated transcription factors that regulate the
expression of genes controlling lipid metabolism. Oxysterols bind LXRs with high affinity in vitro …

Opioid peptides long have been hypothesized to play a role in ethanol reinforcement.
Neuropharmacological studies have shown that opioid receptor antagonists decrease ethanol self-…

To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that promotes
ER+ breast tumor growth. We report that the cholesterol metabolite 27-hydroxycholesterol (…

25-Hydroxycholesterol is produced in mammalian tissues. The function of this oxysterol is
unknown. Here we describe a central role for 25-hydroxycholesterol in regulating the immune …