We sought to define whether there are intrinsic molecular subtypes of high-grade bladder
cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-…

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A …

We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. …

A compounding feature of greater than 50% of all cancers is the high incidence of the
cachexia syndrome, a complex metabolic disorder characterized by extreme weight loss due …

10.7554/eLife.43653.001 Over half of breast-cancer-related deaths are due to recurrence 5
or more years after initial diagnosis and treatment. This latency suggests that a population of …

Background The dismal survival of glioblastoma (GBM) patients urgently calls for the development
of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy…

Nuclear factor-κB (NF-κB) signaling is necessary for many types of muscle atrophy, yet only
some of the required components have been identified. Gene transfer of a dominant …

High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in
underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We …

The transcription factor FOXM1 contributes to cell cycle progression and is significantly
upregulated in basal-like breast cancer (BLBC). Despite its importance in normal and cancer cell …

The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition …