User profiles for Jeffrey T. Mindrebo

Jeffrey T. Mindrebo

Postdoctoral Fellow at Scripps Research
Verified email at scripps.edu
Cited by 327

Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom

JT Mindrebo, CM Nartey, Y Seto, MD Burkart… - Current opinion in …, 2016 - Elsevier
… Author links open overlay panel Jeffrey T Mindrebo 1 2 , Charisse M Nartey 2 , Yoshiya
Seto 2 , Michael D Burkart 1 , Joseph P Noel 2 … Yamaguchi, T. Hakoshima … Li, T.-H. Xu, Y. …

[HTML][HTML] Gating mechanism of elongating β-ketoacyl-ACP synthases

JT Mindrebo, A Patel, WE Kim, TD Davis… - Nature …, 2020 - nature.com
Carbon-carbon bond forming reactions are essential transformations in natural product
biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier …

Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD

LE Misson, JT Mindrebo, TD Davis… - Proceedings of the …, 2020 - National Acad Sciences
Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often
reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of …

[HTML][HTML] Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

M Shin, ER Watson, AS Song, JT Mindrebo… - Nature …, 2021 - nature.com
The human mitochondrial AAA+ protein LONP1 is a critical quality control protease involved
in regulating diverse aspects of mitochondrial biology including proteostasis, electron …

Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases

JT Mindrebo, A Chen, WE Kim, RN Re, TD Davis… - ACS …, 2021 - ACS Publications
Ketosynthases (KSs) catalyze carbon–carbon bond-forming reactions in fatty acid
synthases (FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping-pong kinetic …

Activity mapping the acyl carrier protein: elongating ketosynthase interaction in fatty acid biosynthesis

JT Mindrebo, LE Misson, C Johnson, JP Noel… - Biochemistry, 2020 - ACS Publications
Elongating ketosynthases (KSs) catalyze carbon–carbon bond-forming reactions during the
committed step for each round of chain extension in both fatty acid synthases (FASs) and …

Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states

A Chen, JT Mindrebo, TD Davis, WE Kim… - … Section D: Structural …, 2022 - scripts.iucr.org
Ketosynthases (KSs) catalyse essential carbon–carbon bond-forming reactions in fatty-acid
biosynthesis using a two-step, ping-pong reaction mechanism. In Escherichia coli, there are …

Corrigendum to “Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom”(Current Opinion in Structural Biology (2016) 41 (233 …

JT Mindrebo, CM Nartey, Y Seto… - Current Opinion in …, 2016 - meiji.elsevierpure.com
The authors wish to point out that the following references include errors in the listed
authors and author orders: Ref.[3], Ref.[4], Ref.[6], Ref.[7], Ref.[24], Ref.[41], Ref.[69], and Ref.[73]. …

Structure and Dynamic Basis of Molecular Recognition Between Acyltransferase and Carrier Protein in E. coli Fatty Acid Synthesis

LE Misson, JT Mindrebo, TD Davis, A Patel… - bioRxiv, 2020 - biorxiv.org
Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often
reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of …

Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states

A Chen, JT Mindrebo, TD Davis, WE Kim, Y Katsuyama… - bioRxiv, 2022 - biorxiv.org
Ketosynthases (KS) catalyse essential carbon-carbon bond forming reactions in fatty acid
biosynthesis using a two-step, ping-pong reaction mechanism. In E. coli, there are two …