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Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia
CV Lal, J Kandasamy, K Dolma… - … of Physiology-Lung …, 2018 - journals.physiology.org
The pathogenesis of bronchopulmonary dysplasia (BPD) is not well understood. We
previously identified differences in the airway microbiome at birth between preterm infants who …
previously identified differences in the airway microbiome at birth between preterm infants who …
Vascular endothelial mitochondrial function predicts death or pulmonary outcomes in preterm infants
J Kandasamy, N Olave, SW Ballinger… - American Journal of …, 2017 - atsjournals.org
Rationale: Vascular endothelial mitochondrial dysfunction contributes to the pathogenesis
of several oxidant stress–associated disorders. Oxidant stress is a major contributor to the …
of several oxidant stress–associated disorders. Oxidant stress is a major contributor to the …
[HTML][HTML] B-type natriuretic peptide and mortality in extremely low birth weight infants with pulmonary hypertension: a retrospective cohort analysis
Background B-type natriuretic peptide (BNP) is a strong predictor of mortality in adult patients
with various forms of pulmonary hypertension (PH) and may be a strong prognostic marker …
with various forms of pulmonary hypertension (PH) and may be a strong prognostic marker …
[HTML][HTML] Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function
…, N Kaminski, N Ambalavanan, J Kandasamy - JCI insight, 2023 - ncbi.nlm.nih.gov
Mitochondrial dysfunction at birth predicts bronchopulmonary dysplasia (BPD) in extremely
low–birth weight (ELBW) infants. Recently, nebulized thyroid hormone (TH), given as …
low–birth weight (ELBW) infants. Recently, nebulized thyroid hormone (TH), given as …
Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis
J Kandasamy, S Huda, N Ambalavanan, T Jilling - Pathophysiology, 2014 - Elsevier
Necrotizing enterocolitis is a disease entity with multiple proposed pathways of pathogenesis.
Various combinations of these risk factors, perhaps based on genetic predisposition, …
Various combinations of these risk factors, perhaps based on genetic predisposition, …
[HTML][HTML] Genome sequencing as a first-line diagnostic test for hospitalized infants
…, MB Neu, J Patrick-Esteve, ACE Hurst, J Kandasamy… - Genetics in …, 2022 - Elsevier
Purpose SouthSeq is a translational research study that undertook genome sequencing (GS)
for infants with symptoms suggestive of a genetic disorder. Recruitment targeted racial/…
for infants with symptoms suggestive of a genetic disorder. Recruitment targeted racial/…
[HTML][HTML] Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis
…, TP Atkinson, OM Faye-Petersen, J Kandasamy… - Pediatric …, 2017 - nature.com
Background: Premature rupture of membranes and preterm delivery are associated with
Ureaplasma infection. We hypothesized that Ureaplasma induced extracellular collagen …
Ureaplasma infection. We hypothesized that Ureaplasma induced extracellular collagen …
Mitochondrial DNA variation modulates alveolar development in newborn mice exposed to hyperoxia
J Kandasamy, G Rezonzew, T Jilling… - … of Physiology-Lung …, 2019 - journals.physiology.org
Hyperoxia-induced oxidant stress contributes to the pathogenesis of bronchopulmonary
dysplasia (BPD) in preterm infants. Mitochondrial functional differences due to mitochondrial …
dysplasia (BPD) in preterm infants. Mitochondrial functional differences due to mitochondrial …
[HTML][HTML] Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death
J Kandasamy, C Roane, A Szalai, N Ambalavanan - Pediatric research, 2015 - nature.com
Background: Early systemic inflammation in extremely-low-birth-weight (ELBW) infants is
associated with an increased risk of bronchopulmonary dysplasia (BPD). Our objective was to …
associated with an increased risk of bronchopulmonary dysplasia (BPD). Our objective was to …
Pharmacologic therapies IV: other medications
J Kandasamy, WA Carlo IV - … of the Neonate: An Evidence-Based …, 2016 - books.google.com
Pharmacologic agents are often used during mechanical ventilation of newborn infants to
achieve various therapeutic goals including sedation and analgesia, neuromuscular paralysis, …
achieve various therapeutic goals including sedation and analgesia, neuromuscular paralysis, …