Recent molecular studies have shown that, even when derived from a seemingly homogenous
population, individual cells can exhibit substantial differences in gene expression, protein …

High-throughput single-cell transcriptomics offers an unbiased approach for understanding
the extent, basis and function of gene expression variation between seemingly identical cells…

The number of studies investigating the human gastrointestinal tract using various single-cell
profiling methods has increased substantially in the past few years. Although this increase …

Despite their importance, the molecular circuits that control the differentiation of naive T
cells remain largely unknown. Recent studies that reconstructed regulatory networks in …

Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a
single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. …

A circuit level understanding of immune cells and hematological cancers has been severely
impeded by a lack of techniques that enable intracellular perturbation without significantly …

Single-nucleus RNA-seq (snRNA-seq) enables the interrogation of cellular states in complex
tissues that are challenging to dissociate or are frozen, and opens the way to human …

Developing a detailed understanding of enzyme function in the context of an intracellular
signal transduction pathway requires minimally invasive methods for probing enzyme activity in …

One major goal of cancer genome sequencing is to identify key genes and pathways that
drive tumor pathogenesis. Although many studies have identified candidate driver genes …

γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens
and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-…