Metabolites are active controllers of cellular physiology, but their role in complex behaviors
is less clear. Here we report metabolic changes that occur during the transition between …

Reduced parasitic infection rates in the developed world are suspected to underlie the rising
prevalence of autoimmune disorders. However, the long-term evolutionary consequences …

Studying how different genotypes respond to environmental variation is essential to understand
the genetic basis of adaptation. The Mexican tetra, Astyanax mexicanus, has cave and …

Nutrient availability varies seasonally and spatially in the wild. While many animals, such as
hibernating animals or migrating birds, evolved strategies to overcome periods of nutrient …

Circadian rhythms are nearly ubiquitous throughout nature, suggesting they are critical for
survival in diverse environments. Organisms inhabiting largely arrhythmic environments, such …

Physical inactivity is a scourge to human health, promoting metabolic disease and muscle
wasting. Interestingly, multiple ecological niches have relaxed investment into physical activity…

Insights from organisms, which have evolved natural strategies for promoting survivability
under extreme environmental pressures, may help guide future research into novel …

Metabolites are the intermediates and end products of biochemical reactions that serve
essential roles as energy, signaling, and regulatory molecules (1, 2). The complete set of …

Circadian clocks allow organisms to track and anticipate rhythms in time-giving environmental
cues (Zeitgebers) caused by Earth’s 24-hour rotation. In many organisms, master …

Insights from extreme-adapted organisms, which have evolved natural strategies for promoting
survivability under severe environmental pressures, may help guide future research into …