The mechanisms by which immune checkpoint blockade modulates tumor evolution during
therapy are unclear. We assessed genomic changes in tumors from 68 patients with …

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus
can spread and the ability of a generally mild infection to induce severe morbidity and …

To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates
the actions of a large complement of interferon effector genes (IEGs) that prevent viral …

Breast cancer is the most common noncutaneous malignancy and the second most lethal
form of cancer among women in the United States. It currently affects more than one in ten …

In this article we review the value and utility of the minipig as an animal model in regulatory
toxicity testing. Our review is based on detailed consideration of the comparative biology of …

Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic
approaches to cancer have taken advantage of tumor neoantigens derived from somatic …

The Belmont Report is one of the leading works concerning ethics and health care research.
Its primary purpose is to protect subjects and participants in clinical trials or research studies…

Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical
resection impossible. The mixture of neoplastic and nonneoplastic cells that remain after …

Most therapeutic monoclonal antibodies (mAbs) licensed for human use or in clinical
development are indicated for treatment of patients with cancer and inflammatory/autoimmune …

Genome maintenance and cancer suppression require homologous recombination (HR) DNA
repair. In yeast and mammals, the scaffold protein TOPBP1 Dpb11 has been implicated in …