User profiles for Jennifer A. Collins
 | Jennifer Ann CollinsUBC, BCCA Verified email at cmmt.ubc.ca Cited by 5043 |
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
…, K Roomp, M van Dam, L Yu, C Brewer, JA Collins… - Nature …, 1999 - nature.com
Genes have a major role in the control of high-density lipoprotein (HDL) cholesterol (HDL-C)
levels. Here we have identified two Tangier disease (TD) families, confirmed 9q31 linkage …
levels. Here we have identified two Tangier disease (TD) families, confirmed 9q31 linkage …
Control of gene expression by a natural metabolite-responsive ribozyme
Most biological catalysts are made of protein; however, eight classes of natural ribozymes
have been discovered that catalyse fundamental biochemical reactions. The central functions …
have been discovered that catalyse fundamental biochemical reactions. The central functions …
Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux
Background A low concentration of HDL cholesterol is the most common lipoprotein abnormality
in patients with premature atherosclerosis. We have shown that Tangier disease, a rare …
in patients with premature atherosclerosis. We have shown that Tangier disease, a rare …
[HTML][HTML] Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
…, K Roomp, KY Zwarts, JA Collins… - The Journal of …, 2000 - Am Soc Clin Investig
… Jennifer A. Collins, 4 … Find articles by Collins, J. in: JCI | PubMed | Google Scholar …
Mechanism of mRNA destabilization by the glmS ribozyme
JA Collins, I Irnov, S Baker… - Genes & development, 2007 - genesdev.cshlp.org
An array of highly structured domains that function as metabolite-responsive genetic
switches has been found to reside within noncoding regions of certain bacterial mRNAs. In …
switches has been found to reside within noncoding regions of certain bacterial mRNAs. In …
[HTML][HTML] HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
Huntington disease (HD) results from CAG expansion in the huntingtin (HTT) gene. Although
HD occurs worldwide, there are large geographic differences in its prevalence. The …
HD occurs worldwide, there are large geographic differences in its prevalence. The …
[PDF][PDF] Length of uninterrupted CAG, independent of polyglutamine size, results in increased somatic instability, hastening onset of Huntington disease
GEB Wright, JA Collins, C Kay, C McDonald… - The American Journal of …, 2019 - cell.com
Huntington disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene.
Although the length of this repeat is inversely correlated with age of onset (AOO), it does …
Although the length of this repeat is inversely correlated with age of onset (AOO), it does …
[HTML][HTML] CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup
Huntington disease (HD) is an autosomal-dominant disorder that results from ≥36 CAG
repeats in the HD gene (HTT). Approximately 10% of patients inherit a chromosome that …
repeats in the HD gene (HTT). Approximately 10% of patients inherit a chromosome that …
[HTML][HTML] Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain …
Quantitation of huntingtin protein in the brain is needed, both as a marker of Huntington disease
(HD) progression and for use in clinical gene silencing trials. Measurement of huntingtin …
(HD) progression and for use in clinical gene silencing trials. Measurement of huntingtin …
[HTML][HTML] Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in Huntington disease patients of European ancestry
Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG
repeat expansion in the Huntingtin gene (HTT). Heterozygous polymorphisms in cis with the …
repeat expansion in the Huntingtin gene (HTT). Heterozygous polymorphisms in cis with the …