Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However, compound …

Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology.
Despite extensive characterization of the cell-cycle regulatory network, the molecular …

The field of systems biology is often held back by difficulties in obtaining comprehensive,
high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to …

Cell division entails a sequence of processes whose specific demands for biosynthetic
precursors and energy place dynamic requirements on metabolism. However, little is known …

Protein–metabolite interactions are of crucial importance for all cellular processes but remain
understudied. Here, we applied a biochemical approach named PROMIS, to address the …

Citrate is an intermediate in catabolic as well as biosynthetic pathways and is an important
regulatory molecule in the control of glycolysis and lipid metabolism. Mass spectrometric and …

Live-cell microscopy is a powerful tool that can reveal cellular behavior as well as the
underlying molecular processes. A key advantage of microscopy is that by visualizing biological …

… Author links open overlay panel Jennifer C Ewald … JJ Turner, JC Ewald, JM Skotheim …
Kalashnikova, WH McDonald, JR Yates 3rd, C. Wittenberg …

Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and
are conserved across eukaryotes. Their main and well-studied function lies in the regulation …

Trehalose-6-phosphate is a pivotal regulator of sugar metabolism, growth, and osmotic
equilibrium in bacteria, yeasts, and plants. To directly visualize the intracellular levels of …