User profiles for Jennifer C. Waters

Jennifer C Waters

Harvard Medical School
Verified email at hms.harvard.edu
Cited by 4709

Accuracy and precision in quantitative fluorescence microscopy

JC Waters - 2009 - rupress.org
The light microscope has long been used to document the localization of fluorescent
molecules in cell biology research. With advances in digital cameras and the discovery and …

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

JC Waters, RH Chen, AW Murray… - The Journal of cell …, 1998 - rupress.org
… We then fixed the cells and measured the distance between sister kinetochores in metaphase
cells (36 chromosomes in 6 cells) as described above and in Waters et al. (1996a). We …

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

RH Chen, JC Waters, ED Salmon, AW Murray - Science, 1996 - science.org
The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a
mitotic spindle. The mad (mitotic arrest-deficient) and bub (budding uninhibited by …

Phototoxicity in live fluorescence microscopy, and how to avoid it

J Icha, M Weber, JC Waters, C Norden - BioEssays, 2017 - Wiley Online Library
Phototoxicity frequently occurs during live fluorescence microscopy, and its consequences
are often underestimated. Damage to cellular macromolecules upon excitation light …

[HTML][HTML] Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis

A Salic, JC Waters, TJ Mitchison - Cell, 2004 - cell.com
Drosophila MEI-S332 and fungal Sgo1 genes are essential for sister centromere cohesion
in meiosis I. We demonstrate that the related vertebrate Sgo localizes to kinetochores and is …

Rapid image deconvolution and multiview fusion for optical microscopy

…, H Vishwasrao, S Ganesan, V Prince, JC Waters… - Nature …, 2020 - nature.com
The contrast and resolution of images obtained with optical microscopes can be improved
by deconvolution and computational fusion of multiple views of the same sample, but these …

Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push

JC Waters, RV Skibbens… - Journal of cell …, 1996 - journals.biologists.com
Experimentally introduced tension on kinetochores and their centromeres has been shown
to stabilize kinetochore attachment to microtubules, modify kinetochore directional instability, …

Evaluating performance in three‐dimensional fluorescence microscopy

…, PL Appleton, JR Swedlow, JC Waters - Journal of …, 2007 - Wiley Online Library
In biological fluorescence microscopy, image contrast is often degraded by a high
background arising from out of focus regions of the specimen. This background can be greatly …

Designing a rigorous microscopy experiment: Validating methods and avoiding bias

APT Jost, JC Waters - Journal of Cell Biology, 2019 - rupress.org
Images generated by a microscope are never a perfect representation of the biological
specimen. Microscopes and specimen preparation methods are prone to error and can impart …

[HTML][HTML] Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

…, N Koga, TJ Lambert, D Baker, JC Waters… - Nature …, 2017 - nature.com
Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide
traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular …