Adaptive evolution is a key feature of T cell immunity. During acute immune responses, T
cells harboring high-affinity T cell antigen receptors (TCRs) are preferentially expanded, but …

Latent herpesvirus infections alter immune homeostasis. To understand if this results in
aging-related loss of immune protection against emerging infections, we challenged old mice …

Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has
allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively…

Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based
vaccination purposes as CMV infection induces large numbers of functional effector-like cells that …

10.7554/eLife.07486.001 Signals delivered by costimulatory molecules are implicated in
driving T cell expansion. The requirements for these signals, however, vary from dispensable to …

Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary,
that is characterised by accumulation and maintenance of high numbers of effector …

Cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes life-long latent infection
in a high percentage of the population worldwide. CMV induces the strongest and most …

Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific
CD8 T cells continuously expands mainly during latent infection and establishes a large and …

Cytomegalovirus (CMV) is a ubiquitous virus, causing the most common congenital
infection in humans, yet a vaccine against this virus is not available. Experimental studies of …

Background The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses,
and the ability to engineer the genome of this DNA virus positions CMV-based vaccine …