Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs

…, AH Taylor, J Easterbrook… - Blood, The Journal …, 2020 - ashpublications.org
Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various
anatomical sites during embryonic development. The in vitro differentiation of human pluripotent …

[PDF][PDF] Analysis of the spatiotemporal development of hematopoietic stem and progenitor cells in the early human embryo

J Easterbrook, S Rybtsov, S Gordon-Keylock… - Stem Cell Reports, 2019 - cell.com
Definitive hematopoietic stem cells (HSCs) first emerge in the aorta-gonad-mesonephros (AGM)
region in both mice and humans. An ex vivo culture approach has enabled …

[HTML][HTML] Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells

…, K Soo, LA Stark, AA Ulanicka, JE Easterbrook… - Plos one, 2011 - journals.plos.org
Background Genetic and environmental factors influence susceptibility to Crohn's disease (CD):
NOD2 is the strongest individual genetic determinant and smoking the best-…

Enforced expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic progenitors but has no effect on the maturation of red blood …

…, AH Taylor, RA Axton, J Easterbrook… - Stem Cells …, 2016 - academic.oup.com
As worldwide blood donations decrease and transfusable transmitted infections increase,
intense interest has ensued in deriving red blood cells (RBCs) in vitro from alternative sources …

Concise review: programming human pluripotent stem cells into blood

J Easterbrook, A Fidanza… - British journal of …, 2016 - Wiley Online Library
Blood disorders are treated with cell therapies including haematopoietic stem cell ( HSC )
transplantation as well as platelet and red blood cell transfusions. However the source of cells …

Single cell transcriptome analysis reveals markers of naïve and lineage-primed hematopoietic progenitors derived from human pluripotent stem cells

…, M Lopez-Yrigoyen, AH Taylor, J Easterbrook… - BioRxiv, 2019 - biorxiv.org
During embryogenesis the hematopoietic system develops through distinct waves that generate
progenitors with increasing lineage potential, ultimately producing haematopoietic stem …

Differentiation of haemopoietic stem cells and progenitor cells from human pluripotent stem cells

J Easterbrook, L Forrester, A Medvinsky - The Lancet, 2016 - thelancet.com
Background Induced pluripotent stem cells hold great promise as an unlimited source of
clinical grade immunologically matched haemopoietic stem cells (HSCs) for transplantation. …

Investigating haematopoiesis in the human embryo using an ex vivo culture system

J Easterbrook, S Gordon-Keylock, S Rybtsov… - Experimental …, 2016 - exphem.org
Human embryonic haematopoieis begins in the yolk sac (YS); however, the first definitive
HSCs are found only later in the aorta-gonad-mesonephros (AGM) region, more specifically in …

Single Cell Transcriptome and Pseudotime Analysis of Human Emps Derived From iPSCs Revealed Multiple Origins of Progenitor Cells

…, B Henderson, H Taylor, J Easterbrook… - Experimental …, 2018 - exphem.org
Background: Spinal Muscular Atrophy (SMA) is the most common genetic disorder and presents
the most common cause of infant mortality. To date, patient management is symptomatic …

Time to first plasma exchange in TTP–a regional Scottish experience

C Mullen, L Haskins, J Easterbrook, K Douglas… - 2021 - postersessiononline.eu
Time to first plasma exchange in TTP – a regional Scottish experience Page 1 BSH2022
Poster presented at: Add your logos here RESULTS INTRODUCTION AIMS METHOD …