In this landmark work, the author team led by Dr. Sean Carroll presents the general principles
of the genetic basis of morphological change through a synthesis of evolutionary biology …

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified
in mammals, few have been functionally characterized, leading to debate about their …

To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell
types, including primary and nondividing cells, we are developing lentiviral short hairpin RNA (…

The karyotypic chaos exhibited by human epithelial cancers complicates efforts to identify
mutations critical for malignant transformation. Here we integrate complementary genomic …

Models of mammalian regulatory networks controlling gene expression have been inferred
from genomic data but have largely not been validated. We present an unbiased strategy to …

Understanding the early evolution of animal body plans requires knowledge both of metazoan
phylogeny and of the genetic and developmental changes involved in the emergence of …

Many biological pathways were first uncovered by identifying mutants with visible phenotypes
and by scoring every sample in a screen via tedious and subjective visual inspection. Now…

Animals have evolved diverse appendages adapted for locomotion, feeding and other
functions. The genetics underlying appendage formation are best understood in insects and …

Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular
mechanisms governing control or progression of intracellular infections. In this work, we explore …

Quantitative genetics has primarily focused on describing genetic effects on trait means and
largely ignored the effect of alternative alleles on trait variability, potentially missing an …