In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …

In light of the current outbreak of Ebola virus disease, there is an urgent need to develop
effective therapeutics to treat Ebola infection, and drug repurposing screening is a potentially …

Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal
development of heart and vasculature through activation of apelin receptor (APJ), a G protein-…

We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-based
inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high-…

Although a group of FDA-approved drugs were previously identified with activity against
Ebola virus (EBOV), most of them are not clinically useful because their human blood …

Filoviruses are highly infectious, and no FDA-approved drug therapy for filovirus infection is
available. Most work to find a treatment has involved only a few strains of Ebola virus and …

The conjugation/de-conjugation of Small Ubiquitin-like Modifier (SUMO) has been shown to
be associated with a diverse set of physiologic/pathologic conditions. The clinical …

The development of novel neuroprotective treatments for acute stroke has been fraught with
failures, which supports the view of ischemic brain damage as a highly complex …

Carboxyl-terminal binding protein (CtBP) is a transcriptional corepressor that suppresses
multiple proapoptotic and epithelial genes. CtBP is overexpressed in many human cancers, …

The structure–activity relationship (SAR) study of two chemotypes identified as inhibitors of
the human NAD + -dependent 15-hydroxyprostaglandin dehydrogenase (HPGD, 15-PGDH) …