User profiles for Jennifer L. Gardy

Jennifer Gardy

Bill & Melinda Gates Foundation
Verified email at gatesfoundation.org
Cited by 11321

[HTML][HTML] Whole-genome sequencing and social-network analysis of a tuberculosis outbreak

JL Gardy, JC Johnston, SJH Sui, VJ Cook… - … England Journal of …, 2011 - Mass Medical Soc
Background An outbreak of tuberculosis occurred over a 3-year period in a medium-size
community in British Columbia, Canada. The results of mycobacterial interspersed repetitive unit…

PSORTb v. 2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis

JL Gardy, MR Laird, F Chen, S Rey, CJ Walsh… - …, 2005 - academic.oup.com
Motivation: PSORTb v.1.1 is the most precise bacterial localization prediction tool available.
However, the program's predictive coverage and recall are low and the method is only …

[HTML][HTML] Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
The recent Ebola and Zika epidemics demonstrate the need for the continuous surveillance,
rapid diagnosis and real-time tracking of emerging infectious diseases. Fast, affordable …

PSORT-B: Improving protein subcellular localization prediction for Gram-negative bacteria

JL Gardy, C Spencer, K Wang, M Ester… - Nucleic acids …, 2003 - academic.oup.com
Automated prediction of bacterial protein subcellular localization is an important tool for
genome annotation and drug discovery. PSORT has been one of the most widely used …

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

…, D Kaur, JE Posey, B Plikaytis, MR Oggioni, JL Gardy… - Nature …, 2013 - nature.com
M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic
control. Mechanisms of resistance, including genetic changes favored by selection in …

InnateDB: facilitating systems‐level analyses of the mammalian innate immune response

…, N Richard, MR Laird, A Barsky, JL Gardy… - Molecular systems …, 2008 - embopress.org
Although considerable progress has been made in dissecting the signaling pathways involved
in the innate immune response, it is now apparent that this response can no longer be …

[HTML][HTML] Association between the 2008–09 seasonal influenza vaccine and pandemic H1N1 illness during spring–summer 2009: four observational studies from …

…, H Charest, MÈ Hamelin, G Boivin, JL Gardy… - PLoS …, 2010 - journals.plos.org
Background In late spring 2009, concern was raised in Canada that prior vaccination with the
2008–09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of …

The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis

…, DA Devine, E Dullaghan, JL Gardy… - Infection and …, 2008 - Am Soc Microbiol
Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia,
and strain K12 has reported probiotic effects. An emerging paradigm indicates that …

[HTML][HTML] Metagenomics for pathogen detection in public health

RR Miller, V Montoya, JL Gardy, DM Patrick, P Tang - Genome medicine, 2013 - Springer
Traditional pathogen detection methods in public health infectious disease surveillance rely
upon the identification of agents that are already known to be associated with a particular …

Methods for predicting bacterial protein subcellular localization

JL Gardy, FSL Brinkman - Nature Reviews Microbiology, 2006 - nature.com
The computational prediction of the subcellular localization of bacterial proteins is an important
step in genome annotation and in the search for novel vaccine or drug targets. Since the …