[HTML][HTML] Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
…, RM Quintana, Y An, D Dotzko, JL Gorman… - Nature …, 2021 - nature.com
The most common events in breast cancer (BC) involve chromosome arm losses and gains.
Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from …
Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from …
[HTML][HTML] Angiotensin II evokes angiogenic signals within skeletal muscle through co-ordinated effects on skeletal myocytes and endothelial cells
JL Gorman, STK Liu, D Slopack, K Shariati… - PLoS …, 2014 - journals.plos.org
Skeletal muscle overload induces the expression of angiogenic factors such as vascular
endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2, leading to new …
endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2, leading to new …
Regulation of matrix metalloproteinase expression
JL Gorman, E Ispanovic, TL Haas - Drug Discovery Today: Disease Models, 2011 - Elsevier
The matrix metalloproteinases are a family of matrix degrading enzymes that are important
regulators of extracellular matrix remodelling and cellular function. This article presents a …
regulators of extracellular matrix remodelling and cellular function. This article presents a …
Whole slide Imaging Mass Cytometry allows the rapid profiling of the immune landscape of histopathologically aggressive prostate tumors
JL Gorman, LY Liu, JP Hartig, N Parsotam, A Khoo… - Cancer Research, 2024 - AACR
Patients with Gleason pattern 4 or 5 prostate tumors have a high risk of biochemical
recurrence and worse survival. Affected by their local environment, dynamic immune cell …
recurrence and worse survival. Affected by their local environment, dynamic immune cell …
Development of a drug repressible β-catenin mutant mouse to examine effect of activated β-catenin signaling on long-term maintenance of mammary tumor growth
Stabilized β-catenin expression is a well described initiator of mammary tumorigenesis in the
mouse and elevated nuclear expression of this protein has been observed in human triple-…
mouse and elevated nuclear expression of this protein has been observed in human triple-…
Abstract A29: Generation of a novel transgenic mouse model with regulatable β-catenin expression to examine importance of activated β-catenin signaling to long …
Stabilized β-catenin expression is a well described initiator of mammary tumorigenesis in
the mouse and elevated nuclear expression has been observed in human triple-negative …
the mouse and elevated nuclear expression has been observed in human triple-negative …
Abstract P1-07-24: Modeling breast cancer metastasis in the mouse via measurement of circulating tumor cells
JL Gorman, M Parsons, E Zacksenhaus, S Egan… - Cancer Research, 2015 - AACR
Objectives: Advances in the detection of circulating tumor cells (CTC) in the blood of metastatic
breast cancer patients have indicated that patients with greater than 5 CTC/7.5mL of …
breast cancer patients have indicated that patients with greater than 5 CTC/7.5mL of …
Global Approaches to Understanding Protein Kinase Functions
JL Gorman, JR Woodgett - Kinomics: Approaches and …, 2015 - Wiley Online Library
This chapter initially describes the subclasses of protein kinases, provides examples of their
roles in disease, and discusses methods for their characterization and functional …
roles in disease, and discusses methods for their characterization and functional …
Development and implementation of health care transition resources for youth with autism spectrum disorders within a primary care medical home
JF Harris, LP Gorman, A Doshi, S Swope, SD Page - Autism, 2021 - journals.sagepub.com
Transition from pediatric to adult health care systems presents unique challenges for
adolescents with autism spectrum disorder who often have complex medical and mental health …
adolescents with autism spectrum disorder who often have complex medical and mental health …
Coping in Children and Adolescents: Project KICK--A Primary Prevention Model.
SA Rollin, RI Rubin, TL Shelby, JL Holland-Gorman… - 2000 - ERIC
With the emergence of greater stress in the life of today's youth, much effort has gone into the
investigation of effective coping methods for adolescents. By employing coping strategies, …
investigation of effective coping methods for adolescents. By employing coping strategies, …