Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias
…, AAM Wilde, L Toivonen, W Zareba, JL Robinson… - Circulation, 2001 - Am Heart Assoc
Background—The congenital long-QT syndrome (LQTS) is caused by mutations on several
genes, all of which encode cardiac ion channels. The progressive understanding of the …
genes, all of which encode cardiac ion channels. The progressive understanding of the …
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
…, J Shen, I Splawski, D Atkinson, Z Li, JL Robinson… - Cell, 1995 - cell.com
Long QT syndrome (LQT) is an inherited disorder that causes sudden death from cardiac
arrhythmias, specifically torsade de pointes and ventricular fibrillation. We previously mapped …
arrhythmias, specifically torsade de pointes and ventricular fibrillation. We previously mapped …
Spectrum of Mutations in Long-QT Syndrome Genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
…, KW Timothy, MH Lehmann, S Priori, JL Robinson… - Circulation, 2000 - Am Heart Assoc
Background—Long-QT Syndrome (LQTS) is a cardiovascular disorder characterized by
prolongation of the QT interval on ECG and presence of syncope, seizures, and sudden death. …
prolongation of the QT interval on ECG and presence of syncope, seizures, and sudden death. …
[PDF][PDF] Gut-microbiota-targeted diets modulate human immune status
Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we
determined how two microbiota-targeted dietary interventions, plant-based fiber and …
determined how two microbiota-targeted dietary interventions, plant-based fiber and …
Effectiveness and limitations of β-blocker therapy in congenital long-QT syndrome
…, C Napolitano, A Medina, L Zhang, JL Robinson… - Circulation, 2000 - Am Heart Assoc
Background—β-blockers are routinely prescribed in congenital long-QT syndrome (LQTS),
but the effectiveness and limitations of β-blockers in this disorder have not been evaluated. …
but the effectiveness and limitations of β-blockers in this disorder have not been evaluated. …
[HTML][HTML] Influence of the genotype on the clinical course of the long-QT syndrome
…, PJ Schwartz, GM Vincent, JL Robinson… - … England Journal of …, 1998 - Mass Medical Soc
Background The congenital long-QT syndrome, caused by mutations in cardiac potassium-channel
genes (KVLQT1 at the LQT1 locus and HERG at the LQT2 locus) and the sodium-…
genes (KVLQT1 at the LQT1 locus and HERG at the LQT2 locus) and the sodium-…
Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome
…, JL Robinson, WJ Hall, PA Brink, L Toivonen… - Circulation, 2004 - Am Heart Assoc
Background— The management of long-QT syndrome (LQTS) patients who continue to have
cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of …
cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of …
Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis
BACKGROUND: Although structural neuroimaging methods have been widely used to study
brain morphology in schizophrenia, synthesizing this literature has been difficult. With the …
brain morphology in schizophrenia, synthesizing this literature has been difficult. With the …
ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome
…, J Benhorin, EH Locati, WJ Hall, JL Robinson… - Circulation, 1995 - Am Heart Assoc
Background The long QT syndrome is an inherited disorder with prolonged ventricular
repolarization and a propensity to ventricular tachyarrhythmias and sudden arrhythmic death. …
repolarization and a propensity to ventricular tachyarrhythmias and sudden arrhythmic death. …
Spectrum of ST-T–wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes
…, J Benhorin, AJ Moss, PJ Schwartz, JL Robinson… - Circulation, 2000 - Am Heart Assoc
Background—Congenital long-QT syndrome (LQTS) is caused by mutations of genes encoding
the slow component of the delayed rectifier current (LQT1, LQT5), the rapid component …
the slow component of the delayed rectifier current (LQT1, LQT5), the rapid component …