Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is …
Cellular stress can globally inhibit translation initiation, and glucose removal from yeast
causes one of the most dramatic effects in terms of rapidity and scale. Here we show that the …
causes one of the most dramatic effects in terms of rapidity and scale. Here we show that the …
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals
Gut homing CD4 + T cells expressing the integrin α4β7 are early viral targets and contribute
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …
[PDF][PDF] Granules harboring translationally active mRNAs provide a platform for P-body formation following stress
The localization of mRNA to defined cytoplasmic sites in eukaryotic cells not only allows
localized protein production but also determines the fate of mRNAs. For instance, translationally …
localized protein production but also determines the fate of mRNAs. For instance, translationally …
Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth
M Pizzinga, C Bates, J Lui, G Forte… - Journal of Cell …, 2019 - rupress.org
mRNA localization serves key functions in localized protein production, making it critical that
the translation machinery itself is present at these locations. Here we show that translation …
the translation machinery itself is present at these locations. Here we show that translation …
[HTML][HTML] Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells
IL-2R signaling is essential for regulatory T cell (Treg) function. However, the precise contribution
of IL-2 during Treg thymic development, peripheral homeostasis and lineage stability …
of IL-2 during Treg thymic development, peripheral homeostasis and lineage stability …
mRNA localization to Pbodies in yeast is biphasic with many mRNAs captured in a late Bfr1pdependent wave
CE Simpson, J Lui, CJ Kershaw… - Journal of cell …, 2014 - journals.biologists.com
The relocalization of translationally repressed mRNAs to mRNA processing bodies Pbodies
is a key consequence of cellular stress across many systems. Pbodies harbor mRNA …
is a key consequence of cellular stress across many systems. Pbodies harbor mRNA …
Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance
Real-time imaging studies are reshaping immunological paradigms, but a visual framework
is lacking for self-antigen-specific T cells at the effector phase in target tissues. To address …
is lacking for self-antigen-specific T cells at the effector phase in target tissues. To address …
[PDF][PDF] Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation
F Morales-Polanco, C Bates, J Lui, J Casson, CA Solari… - IScience, 2021 - cell.com
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and
glycolytic enzymes are among the most abundant proteins in cells. Their expression at such …
glycolytic enzymes are among the most abundant proteins in cells. Their expression at such …
Persistent IL-2 receptor signaling by IL-2/CD25 fusion protein controls diabetes in NOD mice by multiple mechanisms
NC Ward, JB Lui, R Hernandez, L Yu, M Struthers… - Diabetes, 2020 - Am Diabetes Assoc
Low-dose interleukin-2 (IL-2) represents a new therapeutic approach to regulate immune
homeostasis to promote immune tolerance in patients with autoimmune diseases, including …
homeostasis to promote immune tolerance in patients with autoimmune diseases, including …
[HTML][HTML] Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control
The regulation of translation provides a rapid and direct mechanism to modulate the cellular
proteome. In eukaryotes, an established model for the recruitment of ribosomes to mRNA …
proteome. In eukaryotes, an established model for the recruitment of ribosomes to mRNA …