Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

B Schrank, R Götz, JM Gunnersen… - Proceedings of the …, 1997 - National Acad Sciences
Proximal spinal muscular atrophy is an autosomal recessive human disease of spinal motor
neurons leading to muscular weakness with onset predominantly in infancy and childhood. …

[HTML][HTML] MAIT cells protect against pulmonary Legionella longbeachae infection

…, JYW Mak, DP Fairlie, Y Iwakura, JM Gunnersen… - Nature …, 2018 - nature.com
Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from
riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate …

[HTML][HTML] Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy

CM Simon, S Rauskolb, JM Gunnersen… - Acta …, 2015 - Springer
Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication
in diabetes. The underlying cellular mechanisms of axon degeneration are poorly …

The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons

S Wiese, MR Digby, JM Gunnersen, R Götz, G Pei… - Nature …, 1999 - nature.com
The avian ITA is homologous to the baculoviral and mammalian inhibitor of apoptosis (IAP)
proteins, which can prevent apoptosis by inhibition of specific caspases. We investigated the …

Legionella protection and vaccination mediated by Mucosal Associated Invariant T (MAIT) cells

…, L Liu, JYW Mak, DP Fairlie, Y Iwakura, JM Gunnersen… - bioRxiv, 2017 - biorxiv.org
Mucosal associated invariant T (MAIT) cells recognize conserved microbial metabolites from
riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate …

TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons

…, JM Gunnersen, M Breuss, M Habgood… - Human molecular …, 2014 - academic.oup.com
The microtubule cytoskeleton is critical for the generation and maturation of neurons in the
developing mammalian nervous system. We have previously shown that mutations in the β-…

Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult

U Schweizer, J Gunnersen, C Karch, S Wiese… - The Journal of cell …, 2002 - rupress.org
Members of the ciliary neurotrophic factor (CNTF)/leukemia inhibitory factor (LIF)/cardiotrophin
gene family are potent survival factors for embryonic and lesioned motoneurons. These …

[HTML][HTML] The proteome of distal nerves: implication in delayed repair and poor functional recovery

S Guo, RM Moore, MC Charlesworth… - Neural Regeneration …, 2022 - journals.lww.com
Chronic denervation is one of the key factors that affect nerve regeneration. Chronic
axotomy deteriorates the distal nerve stump, causes protein changes, and renders the …

The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease

JM Sasser - American Journal of Physiology-Regulatory …, 2013 - journals.physiology.org
Emerging evidence supports a potential therapeutic role of relaxin in fibrotic diseases, including
chronic kidney disease. Relaxin is a pleiotropic hormone, best characterized for its role …

[BOOK][B] CryoEM studies of novel ion channel families involved in cellular sensory processes

JM Kefauver - 2018 - search.proquest.com
… To Angela Glenn and Jenn Rafanan who make our lives less stressful, more organized
and more fun, thank you so much. The work you do can never be appreciated enough. To Bill …