User profiles for Jennifer M. Coughlin
Jennifer M CoughlinAssociate Professor, Johns Hopkins University School of Medicine Verified email at jhmi.edu Cited by 2671 |
Neuroinflammation and brain atrophy in former NFL players: an in vivo multimodal imaging pilot study
There are growing concerns about potential delayed, neuropsychiatric consequences (eg,
cognitive decline, mood or anxiety disorders) of sports-related traumatic brain injury (TBI). …
cognitive decline, mood or anxiety disorders) of sports-related traumatic brain injury (TBI). …
PET imaging of neuroinflammation in neurological disorders
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …
characterise the inflammatory processes underlying various diseases and to inform the …
Imaging of glial cell activation and white matter integrity in brains of active and recently retired national football league players
Importance Microglia, the resident immune cells of the central nervous system, play an
important role in the brain’s response to injury and neurodegenerative processes. It has been …
important role in the brain’s response to injury and neurodegenerative processes. It has been …
Assessing brain metabolism with 7-T proton magnetic resonance spectroscopy in patients with first-episode psychosis
AM Wang, S Pradhan, JM Coughlin, A Trivedi… - JAMA …, 2019 - jamanetwork.com
Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …
regions of a large population of human participants facilitates in vivo study of localized or …
[HTML][HTML] Positron emission tomography studies of the glial cell marker translocator protein in patients with psychosis: a meta-analysis using individual participant data
Background Accumulating evidence suggests that the immune system may be an important
target for new treatment approaches in schizophrenia. Positron emission tomography and …
target for new treatment approaches in schizophrenia. Positron emission tomography and …
Inflammatory molecular signature associated with infectious agents in psychosis
…, KL Gressitt, C Rohleder, JM Coughlin… - Schizophrenia …, 2014 - academic.oup.com
Schizophrenia (SZ) is a devastating mental condition with onset in young adulthood. The
identification of molecular biomarkers that reflect illness pathology is crucial. Recent evidence …
identification of molecular biomarkers that reflect illness pathology is crucial. Recent evidence …
Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV
Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial
cell activation and neuroinflammation, may inform management of individuals infected with …
cell activation and neuroinflammation, may inform management of individuals infected with …
[HTML][HTML] Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis
Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary
in extent between patients. It is unclear whether inter-individual variability in glutamate is …
in extent between patients. It is unclear whether inter-individual variability in glutamate is …
Sulforaphane augments glutathione and influences brain metabolites in human subjects: a clinical pilot study
…, C Higgs, T Tanaka, AM Wang, JM Coughlin… - Molecular …, 2018 - karger.com
Schizophrenia and other neuropsychiatric disorders await mechanism-associated interventions.
Excess oxidative stress is increasingly appreciated to participate in the pathophysiology …
Excess oxidative stress is increasingly appreciated to participate in the pathophysiology …
Evaluation of two intensive care delirium screening tools for non-critically ill hospitalized patients
BACKGROUND: Delirium is a common, yet frequently under-recognized medical/psychiatric
complication for hospitalized patients, associated with substantial morbidity and mortality. …
complication for hospitalized patients, associated with substantial morbidity and mortality. …