Trends obtained from systematic studies based on chain-length variation have provided
valuable insight and understanding into the behavior of m-phenylene ethynylene foldamers. …

Navigating scientific challenges, persevering through difficulties, and coping with failure are
considered hallmarks of a successful scientist. However, relatively few studies investigate …

Here we report an aptamer-based analogue of the widely used sandwich enzyme-linked
immunosorbent assay (ELISA). This assay utilizes the cocaine split aptamer, which is …

Compared with the rapidly expanding set of known biological roles for RNA, the known
chemical diversity of cellular RNA has remained limited primarily to canonical RNA, 3′-…

Despite advances in XNA evolution, the binding capabilities of artificial genetic polymers
are currently limited to protein targets. Here, we describe the expansion of in vitro evolution …

Here we describe the first use of small-molecule binding to direct a chemical reaction between
two nucleic acid strands. The reported reaction is a ligation between two fragments of a …

Biomolecular assembly is a key driving force in nearly all life processes, providing structure,
information storage, and communication within cells and at the whole organism level. These …

Distinguishing between the two enantiomers of a molecule is a challenging task due to their
nearly identical physical properties. Time-consuming chromatography methods are typically …

Nucleic acid aptamers have emerged as a promising alternative to antibodies for use as
recognition elements in therapeutics, bioimaging, and analytical applications. A key benefit that …

Controlling the structure and activity of nucleic acids dramatically expands their potential for
application in therapeutics, biosensing, nanotechnology, and biocomputing. Several …